Effect of saturated fatty acids on tacrolimus-loaded liquid crystalline nanoparticles

Title
Effect of saturated fatty acids on tacrolimus-loaded liquid crystalline nanoparticles
Author(s)
용철순김종오라즈쿠마르타파렌가르잔티아가라쟌유정현유봉규[유봉규]
Keywords
PERCUTANEOUS-ABSORPTION; DELIVERY-SYSTEMS; CYCLOSPORINE-A; DRUG; PHASES; FK-506; TRANSPLANTATION; FORMULATION; LAMELLAR; KIDNEY
Issue Date
201304
Publisher
EDITIONS SANTE
Citation
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, v.23, no.2, pp.137 - 141
Abstract
Liquid crystalline nanoparticles are unique structures that can be used in the delivery of a wide range of pharmaceutical actives. Herein, we studied the effect of saturated fatty acids on tacrolimus-loaded monoolein liquid crystalline nanoparticles stabilized with poloxamer 407. Characterization of nanoparticles included optical and transmission electron microscopy, particle size, and entrapment efficiency analysis. Microscope data suggested the formation of cubosomes for monoolein dispersions, and of hexosomes for monoolein-fatty acid systems. Entrapment efficiency of tacrolimus was as high as 99 % or above. In vitro release study revealed that amount of monoolein and carbon chain lengths of the fatty acid were the factors that affected drug release from the liquid crystalline nanoparticles. Notably, monoolein-fatty acid systems prepared with short chain length, such as lauric and myristic acid, showed markedly sustained release profile of the drug. Hence, appropriate selection of fatty acid can be exploited to achieve desired release profile from monooloein liquid crystalline nanoparticles.
URI
http://hdl.handle.net/YU.REPOSITORY/26095
ISSN
1773-2247
Appears in Collections:
약학대학 > 약학부 > Articles
의과대학 > 영상의학과학교실 > Articles
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