A nationwide seroepidemiology of hepatitis C virus infection in South Korea

Title
A nationwide seroepidemiology of hepatitis C virus infection in South Korea
Author(s)
이헌주정숙향[정숙향]김도영[김도영]김인희[김인희]조영균[조영균]진영주[진영주]김용석[김용석]김만우[김만우]최화영[최화영]최성규[최성규]
Keywords
UNITED-STATES; GENOTYPE DISTRIBUTION; GENERAL-POPULATION; RISK-FACTORS; PREVALENCE; COHORT; MODEL
Issue Date
201304
Publisher
WILEY-BLACKWELL
Citation
LIVER INTERNATIONAL, v.33, no.4, pp.586 - 594
Abstract
Background & Aims The aim of this study was to reveal nationwide seroprevalence of HCV infection in South Korea by a large-scale survey. Methods From January to December 2009, a total of 291314 adults underwent health check-up in 29 centres nationwide. The data concerning anti-HCV antibody and biochemical tests were obtained from all participants. Among subjects with positive anti-HCV, such data as HCV RNA, genotypes and treatment detail were additionally analysed. Results Using an estimated 2009 population of Korea, the age, sex and area-adjusted anti-HCV positive rate was 0.78%. Anti-HCV prevalence in female patients (0.83%) was higher than that in male patients (0.75%). Gradual increase in anti-HCV positivity was observed, from 0.34% in those aged 2029years to 2.31% in those >70years. The age- and sex-adjusted anti-HCV prevalence varied in different areas, being higher in Busan and Jeonnam (1.532.07%), mid-level in Seoul and surrounding districts (0.500.61%) and lower in Jeju (0.23%). The comparative analysis of laboratory variables between anti-HCV (+) and anti-HCV () group revealed significantly higher levels of alanine aminotransferase and lower levels of serum lipids in anti-HCV (+) group. Among 1 718 anti-HCV positive subjects, serum HCV RNA was measured only in 478 people, of whom 268 (56.1%) patients had detectable HCV RNA in serum. Among 50 patients for whom assessment of response to antiviral therapy was feasible, overall sustained virological response was achieved in 84% of patients. Conclusion The prevalence of HCV infection is low in South Korea. Studies to analyse risk factors are warranted to reduce HCV infection.
URI
http://hdl.handle.net/YU.REPOSITORY/26089http://dx.doi.org/10.1111/liv.12108
ISSN
1478-3223
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의과대학 > 내과학교실 > Articles
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