Genome-wide single-nucleotide polymorphism array-based karyotyping in myelodysplastic syndrome and chronic myelomonocytic leukemia and its impact on treatment outcomes following decitabine treatment

Title
Genome-wide single-nucleotide polymorphism array-based karyotyping in myelodysplastic syndrome and chronic myelomonocytic leukemia and its impact on treatment outcomes following decitabine treatment
Author(s)
김민경이준호[이준호]김형준[김형준]김동환[김동환]허정원[허정원]김희진[김희진]김선희[김선희]김성현[김성현]김경하[김경하]도영록[도영록]문영철[문영철]김혁[김혁]김태경[김태경]
Keywords
ACUTE MYELOID-LEUKEMIA; PROGNOSTIC IMPACT; HETEROZYGOSITY; MUTATIONS; AZACITIDINE; DELETION; LESIONS; CANCER; COMMON; TRIAL
Issue Date
201304
Publisher
SPRINGER
Citation
ANNALS OF HEMATOLOGY, v.92, no.4, pp.459 - 469
Abstract
Decitabine is a hypomethylating agent with proven clinical efficacy in myelodysplastic syndrome (MDS). The current study analyzed the role of single nucleotide polymorphism array (SNP-A)-based karyotyping in prediction of clinical outcome in MDS or chronic myelomonocytic leukemia (CMML) patients following decitabine therapy. A total of 61 MDS/CMML patients treated with decitabine were evaluated with Genome-Wide Human SNP 6.0 Array using DNAs derived from marrow samples. The primary endpoint was the best response rate including complete (CR) and partial response (PR) with overall (OS) and event-free survival (EFS) as secondary endpoints. Best response was noted in 14 patients (26.4 %) out of 53 evaluated patients including 12 CR and two PR with median follow-up of 21.6 months. A total of 81 abnormal SNP lesions were found in 25 out of 61 patients (41.0 %). The patients carrying abnormal SNP lesions showed an inferior CR/PR rate (p = 0.002) and showed a trend of worse OS (p = 0.02 in univariate, p = 0.09 in multivariate) compared to those without SNP lesions, but not were associated with inferior EFS. The presence of abnormal SNP lesions in MDS was associated with adverse outcomes following decitabine therapy. Further study is strongly warranted to establish the role of SNP-A karyotyping in MDS.
URI
http://hdl.handle.net/YU.REPOSITORY/26081http://dx.doi.org/10.1007/s00277-012-1635-7
ISSN
0939-5555
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의과대학 > 내과학교실 > Articles
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