Reservoir-based dielectrophoresis for microfluidic particle separation by charge

Title
Reservoir-based dielectrophoresis for microfluidic particle separation by charge
Author(s)
스즈첸Saurin Patel[Saurin Patel]Xiangchun Xuan[Xiangchun Xuan]
Keywords
INSULATOR-BASED DIELECTROPHORESIS; FREE-FLOW ELECTROPHORESIS; ACTIVATED CELL SORTER; SELECTIVE CONCENTRATION; MICROCHANNEL; FRACTIONATION; FORCE; FIELD; MANIPULATION; CAPILLARY
Issue Date
201304
Publisher
WILEY-BLACKWELL
Citation
ELECTROPHORESIS, v.34, no.7, pp.961 - 968
Abstract
The separation of particles from a complex mixture is important to a wide range of applications in industry, biology, medicine etc. This work demonstrates a microfluidic approach to separate similar-sized fluorescent and nonfluorescent particles based upon the difference in their surface charges inside a reservoir. Such a separation exploits the reservoir-based dielectrophoresis, which is induced by the inherent electric field gradient formed at the reservoirmicrochannel junction, to isolate the trapped fluorescent particles within the reservoir from the streaming nonfluorescent particles. The effects of the DC field magnitude (or equivalently the electrokinetic flow magnitude) and the AC field frequency of DC-biased AC electric fields are investigated on particle separation. A numerical model is also developed to simulate the electrokinetic transport behaviors of the two types of particles. This demonstrated reservoir-based dielectrophoresis particle sorter can operate in parallel to increase the flow throughput. It is suitable for integration with other functional parts into lab-on-a-chip devices for diverse particle handling.
URI
http://hdl.handle.net/YU.REPOSITORY/26056http://dx.doi.org/10.1002/elps.201200467
ISSN
0173-0835
Appears in Collections:
공과대학 > 기계공학부 > Articles
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