Cytotoxic scalarane sesterterpenes from a Korean marine sponge Psammocinia sp.

Title
Cytotoxic scalarane sesterterpenes from a Korean marine sponge Psammocinia sp.
Author(s)
최혁재Dongyup Hahn[Dongyup Hahn]Dong Hwan Won[Dong Hwan Won]Bora Mun[Bora Mun]Hiyoung Kim[Hiyoung Kim]Chulkyeong Han[Chulkyeong Han]Weihong Wang[Weihong Wang]Taeho Chun[Taeho Chun]Sunhee Park[Sunhee Park]Dajeong Yoon[Dajeong Yoon]Sang-Jip Nam[Sang-Jip Nam]Merrick Ekins[Merrick Ekins]Jungwook Chin[Jungwook Chin]Heonjoong Kang[Heonjoong Kang]
Keywords
HYRTIOS-ERECTA; HEMIASTERLIN; NUDIBRANCHS; DEFENSE; E7974
Issue Date
201304
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.23, no.8, pp.2336 - 2339
Abstract
Three novel scalarane sesterterpenes were isolated from a Korean marine sponge, Psammocinia sp., along with four known derivatives. Their structures were elucidated on the basis of NMR, MS and IR spectroscopic data. The three new compounds are 12-deacetoxy-23-hydroxyscalaradial (1), 12-dehydroxy-23-hydroxyhyrtiolide (2) and 12-O-acetyl-16-deacetoxy-23-acetoxyscalarafuran (3), respectively, and the four known compounds are 12-deacetoxy-23-hydroxyheteronemin (4), 12-deacetoxy-23-acetoxy-19-O-acetylscalarin (5), 12-deacetoxy-23-O-acetoxyheteronemin (6) and 12-deacetoxyscalaradial (7). They exhibited cytotoxicity against intractable human cancer cell lines A498, ACHN, MIA-paca and PANC-1, with an IC50 range of 0.4-48 mu M. (C) 2013 Elsevier Ltd. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/26046http://dx.doi.org/10.1016/j.bmcl.2013.02.061
ISSN
0960-894X
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약학대학 > 약학부 > Articles
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