Role of formyl peptide receptor 2 on the serum amyloid A-induced macrophage foam cell formation

Title
Role of formyl peptide receptor 2 on the serum amyloid A-induced macrophage foam cell formation
Author(s)
백석환이하영[이하영]김상두[김상두]최준혁배외식[배외식]
Keywords
PROTEIN-COUPLED RECEPTOR; LOW-DENSITY-LIPOPROTEIN; CCL2 PRODUCTION; UP-REGULATION; HUMAN MONOCYTES; TNF-ALPHA; EXPRESSION; ATHEROSCLEROSIS; INFLAMMATION; ACTIVATION
Issue Date
201304
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Citation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.433, no.2, pp.255 - 259
Abstract
Recently we demonstrated that SAA induces macrophage foam cell formation. In this study we show that SAA-induced foam cell formation is inhibited by formyl peptide receptor 2 (FPR2) antagonist WRW4, as well as by FPR2-targeted siRNA knockdown. SAA-stimulated LOX1 expression was also mediated by FPR2. We also found that SAA-stimulated foam cell formation and LOX1 expression was pertussis toxin-insensitive. In addition, FPR2 is upregulated in peripheral blood mononuclear cells from patients with atherosclerosis. Our findings therefore suggest that SAA stimulates foam cell formation via FPR2 signaling and LOX1 induction, and thus likely contributes to atherogenesis. (C) 2013 Elsevier Inc. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/26043http://dx.doi.org/10.1016/j.bbrc.2013.03.002
ISSN
0006-291X
Appears in Collections:
의과대학 > 생화학.분자생물학교실 > Articles
의과대학 > 병리학교실 > Articles
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