Air pollution interacts with past episodes of bronchiolitis in the development of asthma

Title
Air pollution interacts with past episodes of bronchiolitis in the development of asthma
Author(s)
사공준김병주[김병주]서주희[서주희]정영호[정영호]김형영[김형영]권지원[권지원]김효빈[김효빈]이소연[이소연]박강서[박강서]유진호[유진호]김환철[김환철]임종한[임종한]이지영[이지영]김수영[김수영]이철갑[이철갑]강동묵[강동묵]하미나[하미나]권호장[권호장]홍윤철[홍윤철]홍수종[홍수종]
Keywords
ALLERGIC SENSITIZATION; CHILDHOOD ASTHMA; DIESEL EXHAUST; RISK-FACTORS; EXPOSURE; CHILDREN; PREVALENCE; INFECTION; DISEASES; INFANCY
Issue Date
201304
Publisher
WILEY-BLACKWELL
Citation
ALLERGY, v.68, no.4, pp.517 - 523
Abstract
Background Exposure to ambient air pollution and bronchiolitis are risk factors for asthma. The aim of this study was to investigate the effect of air pollution on the development of asthma in children with past episodes of bronchiolitis. Methods A prospective 2-year follow-up survey consisting of parental responses to the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire, and allergy evaluations were conducted in 1743 children with a mean age of 6.8years. Recent 5-year exposure to air pollution was estimated using a geographic information system. Results Higher exposure to ozone was associated with airway hyper-responsiveness (PC2016mg/ml) at enrollment (odds ratio [OR]=1.60, 95% CI [confidence interval]=1.132.27) and with new episodes of wheezing during the 2-year period (OR=1.92, 95% CI=0.963.83). Past episodes of bronchiolitis were associated with both current wheezing and physician-diagnosed asthma. When the two factors were combined, the prevalence of bronchial hyper-reactivity (OR=2.96, 95% CI=1.416.24) and new wheezing (OR=4.17, 95% CI=0.8919.66) as well as current wheezing and physician-diagnosed asthma was even greater (P for trend <0.05 for all). In children with both risk factors, lung function was significantly decreased, with atopic children being particularly vulnerable. Conclusion In children, the interaction between air pollution and past episodes of bronchiolitis resulted in a greater prevalence of asthma and pointed to an association with bronchial hyper-reactivity and decreased lung function. These results suggest mechanisms underlying the development of asthma.
URI
http://hdl.handle.net/YU.REPOSITORY/26017http://dx.doi.org/10.1111/all.12104
ISSN
0105-4538
Appears in Collections:
의과대학 > 예방의학교실 > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE