Combination of gemcitabine and carboplatin as first line treatment in elderly patients or those unfit for cisplatin-based chemotherapy with advanced transitional cell carcinoma of the urinary tract

Title
Combination of gemcitabine and carboplatin as first line treatment in elderly patients or those unfit for cisplatin-based chemotherapy with advanced transitional cell carcinoma of the urinary tract
Author(s)
고영휘Park, Kyong Hwa[Park, Kyong Hwa]Park, Joo Hee[Park, Joo Hee]Lee, Soon Wook[Lee, Soon Wook]Kim, Hye Sook[Kim, Hye Sook](Kang, Sung Gu[(Kang, Sung Gu]Kim, Seung Tae[Kim, Seung Tae]Kang, Seok Ho[Kang, Seok Ho]Park, Young Je[Park, Young Je](Choi, In Keun[(Choi, In Keun]
Keywords
METASTATIC UROTHELIAL CARCINOMA; COOPERATIVE-ONCOLOGY-GROUP; PHASE-II; BLADDER-CANCER; 1ST-LINE TREATMENT; PLUS CISPLATIN; METHOTREXATE; VINBLASTINE; DOXORUBICIN; THERAPY
Issue Date
201304
Publisher
SPRINGER
Citation
CANCER CHEMOTHERAPY AND PHARMACOLOGY, v.71, no.4, pp.1033 - 1039
Abstract
Although cisplatin-based chemotherapy is the standard of care for advanced transitional cell carcinoma, tolerability is a challenging issue in unfit patients. This study was conducted to evaluate the efficacy, toxicity, and tolerability of the combination of gemcitabine and carboplatin in unfit patients with advanced transitional cell carcinoma. Thirty-one patients who had advanced transitional cell carcinoma and one of the following clinical features were evaluated: Eastern Cooperative Oncology Group performance status equal or greater than 2, age older the 75 years or estimated glomerular filtration rate less than 60 ml/min. The patients were treated with carboplatin and gemcitabine delivered every 4 weeks. Of the 31 patients, 71 % had an estimated glomerular filtration rate of less than 60 ml/min, and the remaining patients were treated by this protocol due to poor performance status or age older than 75. The median age of the patients was 74 years old. A total of 162 cycles of treatment were delivered to the patients. The overall response rate was 45.1 %. After the median follow-up of 15 months, the median progression-free survival time was 9.4 months (95 % CI 7.3-11.4) and overall survival time was 20 months (95 % CI 14.9-25.0). Grades 3 and 4 anemia, thrombocytopenia, and neutropenia were observed in 22.6, 6.45, and 6.45 % of patients, respectively. There was no treatment-related mortality in our patient series. The combination of gemcitabine and carboplatin is effective in elderly patients with advanced transitional cell carcinoma or those unfit for cisplatin-based chemotherapy, with manageable toxicity.
URI
http://hdl.handle.net/YU.REPOSITORY/26016http://dx.doi.org/10.1007/s00280-013-2098-9
ISSN
0344-5704
Appears in Collections:
의과대학 > 비뇨기과학교실 > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE