The relationship between metformin and cancer in patients with type 2 diabetes

Title
The relationship between metformin and cancer in patients with type 2 diabetes
Author(s)
원규장문준성정현희윤지성이형우
Keywords
low density lipoprotein cholesterol; metformin; triacylglycerol; adult; albuminuria; article; cancer incidence; cancer risk; cholesterol blood level; controlled study; drug dose comparison; drug response; drug use; female; follow up; gender; human; major clinical study; male; malignant neoplastic disease; non insulin dependent diabetes mellitus; smoking; triacylglycerol blood level
Issue Date
201304
Citation
Diabetes and Metabolism Journal, v.37, no.2, pp.125 - 131
Abstract
Background: Recently, several studies reported that the cancer incidence in type 2 diabetes patients is higher than in the general population. Although a number of risks are shared between cancer and diabetes patients, there have been few studies of its correlation. We evaluated the influences of several factors including low density lipoprotein cholesterol (LDL-C), albuminuria and use of metformin on the risk of cancer in patients with type 2 diabetes. Methods: We enrolled 1,320 patients with at least 5 years of follow-up and 73 patients were diagnosed with cancer during this period. The associations of the risk factors with cancer incidence were evaluated by multiple regression analysis. The subjects were placed into two subgroups based on metformin dosage (<1,000 mg/day, ��=1,000 mg/day) and we compared cancer incidence using analysis of covariance. Results: LDL-C and albuminuria were not significantly correlated with cancer risk. In contrast, metformin showed a reverse correlation with cancer risk (P=0.006; relative risk, 0.574). In the metformin nonadministration group, smoking, male gender, and high triglyceride levels tended to be contributing factors without statistical significance. Cancer occurence was lower in the low dose metformin group (less than 1,000 mg/day) (P=0.00). Conclusion: These results suggest that the administration of low dose metformin in patients with type 2 diabetes may be associated with a reduced risk of cancer. ? 2013 Korean Diabetes Association.
URI
http://hdl.handle.net/YU.REPOSITORY/26015http://dx.doi.org/10.4093/dmj.2013.37.2.125
ISSN
2233-6079
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의과대학 > 내과학교실 > Articles
의과대학 > 영상의학과학교실 > Articles
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