Stem Cells in Inflammatory Bowel Disease New Potential Therapeutic Target

Title
Stem Cells in Inflammatory Bowel Disease New Potential Therapeutic Target
Author(s)
장병익송인환
Keywords
Inflammatory bowel diseases; Therapy; Stem cells
Issue Date
201304
Publisher
대한장연구학회
Citation
Intestinal research, v.11, no.2, pp.79 - 84
Abstract
Understanding of the pathophysiology of inflammatory bowel disease (IBD) is constantly evolving and, recently, a number of biologic agents that selectively target specific molecules or pathways to correct the imbalance of the gut immune system have been developed. Among them, an antibody to tumor necrosis factor (anti-TNF) is the first developed drug which has dramati-cally improved the management of patients with IBD. However, more than one-third of IBD patients do not respond to medica-tions, and there is the problem of antibody formation. Therefore, enormous efforts have been made into the development of novel anti-cytokines and stem cell injection as an alternative to has been made. However, the efficacy and safety of stem cell treatment are under investigation. Some studies have reported very promising data; however, others have shown conflicting results. In addition, most trials involved a very small number of subjects and did not compare stem cell treatment with anti-TNF. The present paper reviews the function and therapeutic mechanism of stem cells for the treatment of IBD. (Intest Res 2013;11:79-84)
URI
http://hdl.handle.net/YU.REPOSITORY/25996
ISSN
1598-9100
Appears in Collections:
의과대학 > 내과학교실 > Articles
의과대학 > 해부학교실 > Articles
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