Globular adiponectin modulates expression of programmed cell death 4 and miR-21 in RAW 264.7 macrophages through the MAPK/NF-kappa B pathway

Title
Globular adiponectin modulates expression of programmed cell death 4 and miR-21 in RAW 264.7 macrophages through the MAPK/NF-kappa B pathway
Author(s)
정병선수베디아미트김미진사로즈네팔이응석김정애손동환[손동환]송경[송경]이성희[이성희]박원상[박원상]박필훈
Keywords
TUMOR-SUPPRESSOR PDCD4; INFLAMMATION; MICRORNAS; CANCER; CONTRIBUTES; ACTIVATION; RESPONSES; DISEASE
Issue Date
201305
Publisher
ELSEVIER SCIENCE BV
Citation
FEBS LETTERS, v.587, no.10, pp.1556 - 1561
Abstract
MicroRNA-21 and programmed cell death 4 (PDCD4), a downstream target of miR-21, mediate diverse physiological responses. Here we demonstrate that globular adiponectin (gAcrp) modulates expression of miR-21 and PDCD4 in RAW 264.7 macrophages. These effects were abrogated by inhibitors of ERK1/2, JNK or NF-kappa B. Conditioned media collected from gAcrp-stimulated RAW 264.7 macrophages caused similar effects as direct gAcrp treatment, showing the paracrine effect of gAcrp. These data indicate that gAcrp modulates the miR-21/PDCD4 axis through the ERK and JNK/NF-kappa B pathways in RAW 264.7 macrophages and further suggest that the miR-21/PDCD4 axis may be a novel target mediating adiponectin-induced biological responses. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/25939http://dx.doi.org/10.1016/j.febslet.2013.03.040
ISSN
0014-5793
Appears in Collections:
약학대학 > 약학부 > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE