Radiologic differences in white matter maturation between preterm and full-term infants: TBSS study
- Radiologic differences in white matter maturation between preterm and full-term infants: TBSS study
- 손수민; 장성호; 안상호; 이은실; 이아영; 조희경; 조해민
- WEIGHT PREMATURE-INFANTS; NERVOUS-SYSTEM MYELINATION; CORPUS-CALLOSUM; EQUIVALENT AGE; SPATIAL STATISTICS; COGNITIVE-DEVELOPMENT; DIFFUSION ANISOTROPY; EARLY INTERVENTION; IMAGING FINDINGS; BORN PRETERM
- Issue Date
- PEDIATRIC RADIOLOGY, v.43, no.5, pp.612 - 619
- Widespread white matter (WM) pathology in preterm children has been proposed. The purpose of this study was to investigate maturational differences of WM between preterm infants with thinning of the corpus callosum and full-term infants. A total of 18 preterm children and 18 full-term children were divided into three subgroups according to the corrected age at the time of diffusion tensor imaging scanning. Tract-based spatial statistics was used for assessing differences in fractional anisotropy (FA) between preterm and full-term children, and between each age-related subgroup in preterm and in full-term children. In the preterm group, FA values of overall WM showed an increase with age. This trend indicates that WM maturation is a gradual occurrence during a child's first 2 years. In the full-term group, most WM structures had reached maturation at around 1 year of age; however, centrum semiovale level showed sustained maturation during the first 2 years. Results of our study demonstrate radiologic maturational differences of WM and provide evidence of the need for therapeutic intervention within 2 years of birth to prevent specific functional impairment and to improve clinical outcome in preterm children.
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