Radiologic differences in white matter maturation between preterm and full-term infants: TBSS study

Title
Radiologic differences in white matter maturation between preterm and full-term infants: TBSS study
Author(s)
손수민장성호안상호이은실이아영조희경조해민
Keywords
WEIGHT PREMATURE-INFANTS; NERVOUS-SYSTEM MYELINATION; CORPUS-CALLOSUM; EQUIVALENT AGE; SPATIAL STATISTICS; COGNITIVE-DEVELOPMENT; DIFFUSION ANISOTROPY; EARLY INTERVENTION; IMAGING FINDINGS; BORN PRETERM
Issue Date
201305
Publisher
SPRINGER
Citation
PEDIATRIC RADIOLOGY, v.43, no.5, pp.612 - 619
Abstract
Widespread white matter (WM) pathology in preterm children has been proposed. The purpose of this study was to investigate maturational differences of WM between preterm infants with thinning of the corpus callosum and full-term infants. A total of 18 preterm children and 18 full-term children were divided into three subgroups according to the corrected age at the time of diffusion tensor imaging scanning. Tract-based spatial statistics was used for assessing differences in fractional anisotropy (FA) between preterm and full-term children, and between each age-related subgroup in preterm and in full-term children. In the preterm group, FA values of overall WM showed an increase with age. This trend indicates that WM maturation is a gradual occurrence during a child's first 2 years. In the full-term group, most WM structures had reached maturation at around 1 year of age; however, centrum semiovale level showed sustained maturation during the first 2 years. Results of our study demonstrate radiologic maturational differences of WM and provide evidence of the need for therapeutic intervention within 2 years of birth to prevent specific functional impairment and to improve clinical outcome in preterm children.
URI
http://hdl.handle.net/YU.REPOSITORY/25936http://dx.doi.org/10.1007/s00247-012-2545-5
ISSN
0301-0449
Appears in Collections:
의과대학 > 재활의학교실 > Articles
의과대학 > 소아청소년과학교실 > Articles
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