Cingulum injury in patients with diffuse axonal injury: A diffusion tensor imaging study

Title
Cingulum injury in patients with diffuse axonal injury: A diffusion tensor imaging study
Author(s)
장성호김성호김오룡변우목김민수서정표장민철
Keywords
TRAUMATIC BRAIN-INJURY; FORNIX INJURY; TRACTOGRAPHY; ANATOMY; CORTEX
Issue Date
201305
Publisher
ELSEVIER IRELAND LTD
Citation
NEUROSCIENCE LETTERS, v.543, pp.47 - 51
Abstract
Accurate assessment of the cingulum is difficult, because it is a long neural tract that extends from the orbitofrontal cortex to the medial temporal lobe. We divided the cingulum into five parts and investigated changes caused by injury in these regions in patients with diffuse axonal injury (DAI) using diffusion tensor tractography (DTT). Twenty-one patients with DAI and 21 control subjects were recruited. The cingulum was divided into; the anterior, superior (the anterior and posterior portions), posterior, and inferior regions. Fractional anisotropy (FA), apparent diffusion coefficient (ADC), and tract number were measured in each region. FA values and tract numbers in the patient group were lower in the anterior superior cingulum than in controls (p<0.05); whereas the ADC values in the patient group were higher in the anterior and posterior superior cingulum than in controls (p<0.05). In the superior cingulum, increases in the ADC values of the anterior portion (Delta 8.1%) were higher than those of the posterior portion (Delta 5.5%). We found that the superior cingulum was injured in patients with DAI, and that the anterior portion of the superior cingulum was more injured than the posterior portion. Consequently, the superior cingulum appears to be a vulnerable area and the anterior superior cingulum appears more vulnerable than the posterior superior cingulum in DAI. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/25933http://dx.doi.org/10.1016/j.neulet.2013.02.058
ISSN
0304-3940
Appears in Collections:
의과대학 > 재활의학교실 > Articles
의과대학 > 신경외과학교실 > Articles
의과대학 > 영상의학과학교실 > Articles
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