Anti-biofilm activities of quercetin and tannic acid against Staphylococcus aureus

Title
Anti-biofilm activities of quercetin and tannic acid against Staphylococcus aureus
Author(s)
이진태조무환주상우이진형박주현조현섭
Keywords
ALPHA-HEMOLYSIN; EPIDERMIDIS; INFECTIONS; PRODUCTS; TOXIN; ICA
Issue Date
201305
Publisher
TAYLOR & FRANCIS LTD
Citation
BIOFOULING, v.29, no.5, pp.491 - 499
Abstract
Staphylococcus aureus is a leading cause of nosocomial infections because of its resistance to diverse antibiotics. The formation of a biofilm is one of the mechanisms of drug resistance in S. aureus. The anti-biofilm abilities of 498 plant extracts against S. aureus were examined. Seventy-two plant extracts belonging to 59 genera and 38 families were found to significantly inhibit the formation of biofilms of S. aureus without affecting the growth of planktonic cells. The most active extract, from Alnus japonica, inhibited the formation of biofilms by three S. aureus strains by >70% at 20gml(-1). Transcriptional analyses showed that extract of A. japonica repressed the intercellular adhesion genes icaA and icaD most markedly. Quercetin and tannic acid are major anti-biofilm compounds in the extract of A. japonica. Additionally, the extract of A. japonica and its component compound quercetin, reduced hemolysis by S. aureus. This phenomenon was not observed in the treatment with tannic acid. This study suggests that various plant extracts, such as quercetin and tannic acid, could be used to inhibit the formation of recalcitrant biofilms of S. aureus.
URI
http://hdl.handle.net/YU.REPOSITORY/25927http://dx.doi.org/10.1080/08927014.2013.788692
ISSN
0892-7014
Appears in Collections:
공과대학 > 화학공학부 > Articles
공과대학 > 기계공학부 > Articles
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