Transthyretin Is a Key Regulator of Myoblast Differentiation

Title
Transthyretin Is a Key Regulator of Myoblast Differentiation
Author(s)
최인호이은주압둘루프바트마지드라술캄리무드바리스미리티전태훈[전태훈]이용호[이용호]남상섭[남상섭]남주현[남주현]홍성구[홍성구]양보석[양보석]정기용[정기용]김상훈[김상훈]
Keywords
SKELETAL-MUSCLE; CALCIUM-CHANNELS; GENE-EXPRESSION; THYROID-HORMONE; RESPONSE ELEMENT; T-LYMPHOCYTES; CA2+ ENTRY; FUSION; CELLS; MYOGENESIS
Issue Date
201305
Publisher
PUBLIC LIBRARY SCIENCE
Citation
PLOS ONE, v.8, no.5
Abstract
Transthyretin (TTR) is a known carrier protein for thyroxine (T-4) and retinol-binding protein in the blood that is primarily synthesized in the liver and choroid plexus of the brain. Herein, we report that the TTR gene is expressed in skeletal muscle tissue and up-regulated during myotube formation in C2C12 cells. TTR silencing (TTRkd) significantly reduced myogenin expression and myotube formation, whereas myogenin silencing (MYOG(kd)) did not have any effect on TTR gene expression. Both TTRkd and MYOG(kd) led to a decrease in calcium channel related genes including Cav1.1, STIM1 and Orai1. A significant decrease in intracellular T-4 uptake during myogenesis was observed in TTRkd cells. Taken together, the results of this study suggest that TTR initiates myoblast differentiation via affecting expression of the genes involved during early stage of myogenesis and the genes related to calcium channel.
URI
http://hdl.handle.net/YU.REPOSITORY/25924http://dx.doi.org/10.1371/journal.pone.0063627
ISSN
1932-6203
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