Three-dimensional porous HPMA-co-DMAEM hydrogels for biomedical application

Title
Three-dimensional porous HPMA-co-DMAEM hydrogels for biomedical application
Author(s)
최순모딥티싱조용우[조용우]오태환한성수
Keywords
DRUG-RELEASE; IN-VITRO; PH; DELIVERY; COPOLYMERS; BIOMATERIALS; DOXORUBICIN; TEMPERATURE; BIOSENSORS; PRESSURE
Issue Date
201305
Publisher
SPRINGER
Citation
COLLOID AND POLYMER SCIENCE, v.291, no.5, pp.1121 - 1133
Abstract
The aim of this work is to develop a novel biocompatible drug delivery carrier and tissue engineering scaffold with the ability of controlled drug release and also tissue regeneration. We have synthesized N-(2-hydroxypropyl)methacrylamide and 2-(dimethylamino)ethyl methacrylate copolymer-based hydrogels loaded with doxorubicin and tested in vitro. The manifestation of temperature sensitivity is noted with a sharp decrease or increase in hydrogel optical transparency that happens with the temperature exceeding a critical transition value. The drug release profile exhibited pH-sensitive behavior of the hydrogel. The hydrolytic degradation of gel and in vitro studies of polymer-doxorubicin conjugate and doxorubicin release from hydrogel matrix indicated that hydrogels were stable under acidic conditions (in buffers at pH 4.64 and 6.65). In both drug forms, polymer-doxorubicin conjugate and free doxorubicin could be released from the hydrogel scaffold at a rate depending directly on either the rate of drug diffusion from the hydrogel or rate of hydrogel degradation or at rate controlled by a combination of the both processes. In vitro analysis showed homogenous cell attachment and proliferation on synthesized hydrogel matrix. In vivo implantation demonstrated integration of the gel with the surrounding tissue of mice within 2 weeks and prominent neo-angiogenesis observed in the following weeks. This multifunctional hydrogels can easily overcome biological hurdles in the in vivo conditions where the pH range changes drastically and could attain higher site-specific drug delivery improving the efficacy of the treatment in various therapeutical applications, especially in cancer therapy, and could also be used as tissue engineering scaffold due to its porous interconnected and biocompatible behavior.
URI
http://hdl.handle.net/YU.REPOSITORY/25913http://dx.doi.org/10.1007/s00396-012-2837-1
ISSN
0303-402X
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공과대학 > 융합섬유공학과 > Articles
공과대학 > 화학공학부 > Articles
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