Progress in the studies on tryptanthrin, an alkaloid of history

Title
Progress in the studies on tryptanthrin, an alkaloid of history
Author(s)
장영동
Keywords
POLYGONUM-TINCTORIUM LOUR; BREAST-CANCER CELLS; ONE-POT SYNTHESIS; ISATIS-TINCTORIA; LEUKEMIA-CELLS; ANTIMICROBIAL ACTIVITY; COUROUPITA-GUIANENSIS; CHEMICAL-CONSTITUENTS; BIOLOGICAL-PROPERTIES; INDOLIC CONSTITUENTS
Issue Date
201305
Publisher
PHARMACEUTICAL SOC KOREA
Citation
ARCHIVES OF PHARMACAL RESEARCH, v.36, no.5, pp.517 - 535
Abstract
Tryptanthrin, an indoloquinazoline alkaloid, was first obtained by sublimation of natural indigo and later isolated from the culture of fungus Candida lipolytica and a variety of other natural sources. Tryptanthrin showed a variety of intriguing biological properties such as antibacterial, antifungal, antiprotozoal, and antiparasitic activities, inhibitory activities against COX-2, 5-LOX, NO synthase and PGE(2) expression, as well as cytotoxic and antitumor activities. Present review covers recent studies on the natural sources, biological activities and mechanisms of their actions, synthesis, structure-activity relationship, and metabolism of tryptanthrin.
URI
http://hdl.handle.net/YU.REPOSITORY/25904http://dx.doi.org/10.1007/s12272-013-0091-9
ISSN
0253-6269
Appears in Collections:
약학대학 > 약학부 > Articles
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