Glycogen synthase kinase 3 alpha phosphorylates and regulates the osteogenic activity of Osterix

Title
Glycogen synthase kinase 3 alpha phosphorylates and regulates the osteogenic activity of Osterix
Author(s)
정태천Li H[Li H]정형민[정형민]최유희[최유희]이성호[이성호]정혜광[정혜광]이광열[이광열]
Keywords
TRANSCRIPTION FACTOR OSTERIX; ACTIVATED PROTEIN-KINASE; OSTEOBLAST DIFFERENTIATION; BETA-CATENIN; EXPRESSION; SP7; OSX; PATHWAYS; PROMOTER; CELLS
Issue Date
201305
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Citation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.434, no.3, pp.653 - 658
Abstract
Osteoblast-specific transcription factor Osterix is a zinc-finger transcription factor that required for osteoblast differentiation and new bone formation. The function of Osterix can be modulated by post-translational modification. Glycogen synthase kinase 3 alpha (GSK3 alpha) is a multifunctional serine/threonine protein kinase that plays a role in the Wnt signaling pathways and is implicated in the control of several regulatory proteins and transcription factors. In the present study, we investigated how GSK3 alpha regulates Osterix during osteoblast differentiation. Wide type GSK3 alpha up-regulated the protein level, protein stability and transcriptional activity of Osterix. These results suggest that GSK3 alpha regulates osteogenic activity of Osterix. (C) 2013 Elsevier Inc. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/25899http://dx.doi.org/10.1016/j.bbrc.2013.03.137
ISSN
0006-291X
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약학대학 > 약학부 > Articles
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