Tianeptine combination for partial or non-response to selective serotonin re-uptake inhibitor monotherapy

Title
Tianeptine combination for partial or non-response to selective serotonin re-uptake inhibitor monotherapy
Author(s)
구본훈박원명[박원명]우영섭[우영섭]정종현[정종현]이성환[이성환]김원[김원]성형모[성형모]배치운[배치운]
Keywords
TREATMENT-RESISTANT DEPRESSION; MAJOR DEPRESSION; DOUBLE-BLIND; RAT-BRAIN; ANTIDEPRESSANT TIANEPTINE; REFRACTORY DEPRESSION; GENERAL-PRACTICE; AUGMENTATION; FLUOXETINE; EFFICACY
Issue Date
201305
Publisher
WILEY-BLACKWELL
Citation
PSYCHIATRY AND CLINICAL NEUROSCIENCES, v.67, no.4, pp.219 - 227
Abstract
Aims The goal of this study was to assess the efficacy and tolerability of tianeptine in combination with selective serotonin re-uptake inhibitor (SSRI) in partial responders or non-responders to SSRI monotherapy. Methods In this prospective, open-label, 6-week study, 150 patients with major depressive disorder who had previously not responded or partially responded to SSRI monotherapy were recruited. Tianeptine was given in combination with an SSRI for 6 weeks. Results Significant improvements were observed in the mean scores of the Hamilton Depression Rating Scale (HDRS), Montgomery angstrom sberg Depression Rating Scale (MADRS), and Clinical Global ImpressionSeverity (CGI-S). The change in the mean HDRS, MADRS, and CGI-S scores was significant from week 1. The response rates were 64.7% (HDRS) and 68.7% (MADRS), and the remission rates were 34.0% (HDRS) and 42.0% (MADRS) at week 6. Thirty-six patients (24.0%) reported adverse events that were determined by the investigator to be related to one of the study drugs. The tianeptine and SSRI combination was generally well-tolerated. Conclusions A combination strategy with tianeptine may be an effective and well-tolerated tool for patients who have failed to adequately respond to SSRI monotherapy.
URI
http://hdl.handle.net/YU.REPOSITORY/25895http://dx.doi.org/10.1111/pcn.12042
ISSN
1323-1316
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의과대학 > 정신건강의학교실 > Articles
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