IL-17A promotes transdifferentiation of mouse myoblast cells (C2C12) into adipocytes by increasing the expression of peroxisome proliferator-activated receptor gamma through CAAT/enhancer binding protein beta signaling

Title
IL-17A promotes transdifferentiation of mouse myoblast cells (C2C12) into adipocytes by increasing the expression of peroxisome proliferator-activated receptor gamma through CAAT/enhancer binding protein beta signaling
Author(s)
최인호이석준[이석준]이은주김상훈[김상훈]이동목이현정[이현정]윤두학[윤두학]전태훈[전태훈]
Keywords
ADIPOSE-TISSUE; INSULIN-RESISTANCE; 3T3-L1 ADIPOCYTES; INFLAMMATION; OBESITY; CYTOKINES; FAMILY
Issue Date
201101
Publisher
SPRINGER
Citation
BIOTECHNOLOGY LETTERS, v.33, no.2, pp.229 - 235
Abstract
Helper 17 T (Th17) effector cells are a recently identified Th subset and possess a unique property that distinguishes them from Th1 and Th2 subsets. The functional role of Th17 effector cells involves inflammatory responses, including autoimmunity and infection of specific pathogens. Therefore, IL-17A and its receptors may play a key role in determining the progression of certain inflammatory reactions. However, the relationship between IL-17A and adipogenesis has not yet been examined. Therefore, in this study, the effect of IL-17A on the adipogenic transdifferentiation of mouse myoblast (C2C12) cells was examined. CAAT/enhancer binding-protein beta (C/EPB beta) signaling through the IL-17A receptor promoted adipogenic transdifferentiation of myoblast cells by activating peroxisome proliferator-activated receptor gamma (PPAR gamma). These results will advance our understanding of the physiological function of IL-17A in myoblasts during inflammation, as well as the relationship between adipogenesis and inflammation.
URI
http://hdl.handle.net/YU.REPOSITORY/25790http://dx.doi.org/10.1007/s10529-010-0440-4
ISSN
0141-5492
Appears in Collections:
생명공학부 > 생명공학부 > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE