Full metadata record

DC FieldValueLanguage
dc.contributor.author홍남주ko
dc.contributor.author신재식[신재식]ko
dc.contributor.author홍성우[홍성우]ko
dc.contributor.author이진견[이진견]ko
dc.contributor.author이영민[이영민]ko
dc.contributor.author김대원[김대원]ko
dc.contributor.author김지은[김지은]ko
dc.contributor.author정다정[정다정]ko
dc.contributor.author안성권[안성권]ko
dc.contributor.author김대진[김대진]ko
dc.contributor.author진동훈[진동훈]ko
dc.contributor.author이석용[이석용]ko
dc.date.accessioned2015-12-17T01:37:24Z-
dc.date.available2015-12-17T01:37:24Z-
dc.date.created2015-11-13-
dc.date.issued201101-
dc.identifier.citationINTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, v.27, no.3, pp.401 - 405-
dc.identifier.issn1107-3756-
dc.identifier.urihttp://hdl.handle.net/YU.REPOSITORY/25786-
dc.identifier.urihttp://dx.doi.org/10.3892/ijmm.2011.599-
dc.description.abstractIris nertschinskia, an ornamental plant, is utilized in traditional East Asian medicine for the treatment of skin diseases. However, the biological activity underlying its therapeutic effects remains to be established. In this study, we investigated the anti-tumor effect of the plant extract on MCF7 human breast cancer cells. An ethanol extract of Iris nertschinskia triggered cell death in a dose-dependent manner. Moreover, treatment with the extract promoted p53 phosphorylation in MCF7 cells. Increased phosphorylation of p53, in turn, led to induction of Bax protein, a key regulator of p53-dependent apoptotic cell death, as well as of caspase-7 cleavage in MCF7 cells. Consistently, cells treated with p53-specific siRNA or the caspase inhibitor, Z-VAD, resisted apoptotic cell death induced by the Iris nertschinskia extract. Our results suggest that p53 sensitizes tumor cells to the ethanol extract of Iris nertschinskia by Bax protein induction and caspase-dependent apoptosis.-
dc.language영어-
dc.publisherSPANDIDOS PUBL LTD-
dc.subjectCYTOCHROME-C RELEASE-
dc.subjectWILD-TYPE P53-
dc.subjectBCL-XL-
dc.subjectBAX-
dc.subjectMITOCHONDRIA-
dc.subjectPATHWAY-
dc.subjectDEATH-
dc.subjectINDUCTION-
dc.subjectTHERAPY-
dc.subjectCASCADE-
dc.titleAn ethanol extract of Iris nertschinskia induces p53-dependent apoptosis in the MCF7 human breast cancer cell line-
dc.typeArticle-
dc.identifier.wosid000287783600013-
dc.identifier.scopusid2-s2.0-79551585578-
Appears in Collections:
생명공학부 > 생명공학부 > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE