Asterosaponins Isolated from the Starfish Asterias amurensis

Title
Asterosaponins Isolated from the Starfish Asterias amurensis
Author(s)
나민균황인현김동우[김동우]김수정[김수정]민병선[민병선]이승호손종근김철호[김철호]장현욱
Keywords
STEROIDAL GLYCOSIDE SULFATES; SOFT-SEDIMENT ASSEMBLAGES; ACANTHASTER-PLANCI L; CULCITA-NOVAEGUINEAE; SAPONINS; OLIGOGLYCOSIDES; VARIABILITY; ASTEROIDEA; IMPACT
Issue Date
201101
Publisher
PHARMACEUTICAL SOC JAPAN
Citation
CHEMICAL & PHARMACEUTICAL BULLETIN, v.59, no.1, pp.78 - 83
Abstract
Three new asterosaponins 1-3 and four known saponins 4-7 have been Isolated from the starfish Asterias amurensis LUTKEN By means of high magnetic field 1D- and 2D-NMR (H-1-H-1 correlation spectroscopy (COSY), total correlation spectroscopy (TOCSY), heteronuclear multiple quantum coherence (HMQC), heteronuclear single quantum coherence (HSQC), heteronuclear multiple bond correlation (HMBC), and nuclear Overhauser effect spectroscopy (NOESY)) and MS analyses, the chemical structures of new compounds were determined to be 6 alpha-O-[beta-D-fucopyranosyl-(1 -> 2)-beta-D-galactopyranosyl-(1 -> 4)-[beta-D-quinovopyranosyl-(1 -> 2)-beta-D-quinovopyranosyl-(1 -> 3)-beta-D-galactopyranosyl]-5 alpha-chol-9(11)-en-23-one-3 beta-yl sodium sulfate (1), 6 alpha-O-[beta-D-fucopyranosyl-(1 -> 2)-beta-D-galactopyranosyl-(1 -> 4)-[beta-D-quinovopyranosyl-(1 -> 2)]-beta-D-quinovopyranosyl-(1 -> 3)-beta-D-galactopyranosyl]-5 alpha-cholesta-9(11),24-dien-23-one-3 beta-yl sodium sulfate (2), and 6 alpha-O-[beta-D-fucopyranosyl-(1 -> 2)-beta-D-galactopyranosyl-(1 -> 4)-[beta-D-quinovopyranosyl-(1 -> 2)]-beta-D-quinovopyranosyl-(1 -> 3)-beta-D-galactopyranosyl]-5 alpha-cholest-9(11)-en-23-one-3 beta-yl sodium sulfate (3) In addition, the NMR data for known saponins 4-7 were completely assigned by extensive 2D-NMR analysis without chemical degradation
URI
http://hdl.handle.net/YU.REPOSITORY/25782http://dx.doi.org/10.1248/cpb.59.78
ISSN
0009-2363
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약학대학 > 약학부 > Articles
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