Anti-asthmatic effects of Angelica dahurica against ovalbumin-induced airway inflammation via upregulation of heme oxygenase-1

Title
Anti-asthmatic effects of Angelica dahurica against ovalbumin-induced airway inflammation via upregulation of heme oxygenase-1
Author(s)
손종근이미영[이미영]서창섭[서창섭]이진아[이진아]이남훈[이남훈]김정훈[김정훈]하혜경[하혜경]정명선신현규[신현규]
Keywords
NECROSIS-FACTOR-ALPHA; MURINE MODEL; LUNG INFLAMMATION; OXIDATIVE STRESS; CARBON-MONOXIDE; NADPH OXIDASE; ASTHMA MODEL; MAST-CELLS; T-CELLS; EXPRESSION
Issue Date
201101
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
FOOD AND CHEMICAL TOXICOLOGY, v.49, no.4, pp.829 - 837
Abstract
Asthma is a chronic immune inflammatory disease characterized by variable airflow obstruction. The present study was undertaken to assess the effects of an Angelica dahurica Bentham et Hooker ethanolic extract (AD) on airway inflammation in an ovalbumin (OVA)-induced airway inflammation model. Mice that received AD displayed significantly lower airway eosinophilia, cytokine levels, including interleukin (IL)-4, IL-5, and tumor necrosis factor (TNF)-alpha levels, mucus production and immunoglobulin (Ig)E, compared with OVA-induced mice. In our experiments, AD treatment reduced airway inflammation and suppressed oxidative stress in the OVA-induced asthma model, partly via induction of heme oxygenase (HO)-1. The effects of AD on OVA-induced HO-1 induction were partially reversed by the HO-1 inhibitor, tin protoporphyrin (SnPP). Our results clearly indicate that AD is a suppressor of airway allergic inflammation, and may thus be effectively used as an anti-inflammatory drug in the treatment of asthma. Crown Copyright (C) 2010 Published by Elsevier Ltd. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/25781http://dx.doi.org/10.1016/j.fct.2010.12.004
ISSN
0278-6915
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약학대학 > 약학부 > Articles
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