Donepezil treatment in Alzheimer's disease patients with and without cerebrovascular lesions: A preliminary report

Title
Donepezil treatment in Alzheimer's disease patients with and without cerebrovascular lesions: A preliminary report
Author(s)
박미영나혜리[나혜리]김상윤[김상윤]최성혜[최성혜]양동원[양동원]배희준[배희준]김정은[김정은]심용수[심용수]김병건[김병건]권재철[권재철]유봉구[유봉구]김병채[김병채]이정석[이정석]
Keywords
VASCULAR COGNITIVE IMPAIRMENT; PLACEBO-CONTROLLED TRIAL; LONG-TERM EFFICACY; DOUBLE-BLIND; NEUROPSYCHIATRIC INVENTORY; GLOBAL FUNCTION; US MULTICENTER; OPEN-LABEL; DEMENTIA; SAFETY
Issue Date
201101
Publisher
WILEY-BLACKWELL
Citation
GERIATRICS & GERONTOLOGY INTERNATIONAL, v.11, no.1, pp.90 - 97
Abstract
Aim: Donepezil has not been evaluated in Korean patients with Alzheimer's disease (AD) for up to 1 year. The objectives of this study were to evaluate the differential efficacy of donepezil in Korean AD patients with and without concomitant cerebrovascular lesions (CVL). Methods: This study was a 48-week open-label trial of donepezil in patients with probable AD of mild to moderate severity. CVL were evaluated through magnetic resonance imaging (MRI) findings within 3 months. Efficacy analyses were performed for cognitive, behavioral and functional outcome measures. Results: Concomitant CVL were documented in 35 (30.7%) of the patients on MRI. Seventy-nine (69.3%) of the patients were considered not to have concomitant CVL. The mean Mini-Mental State Examination scores of both patients with and without CVL showed improvement at each evaluation. However, there was no statistical difference in improvement between the groups. Conclusion: The presence of CVL should not deter clinicians from treating AD with donepezil. Geriatr Gerontol Int 2011; 11: 90-97.
URI
http://hdl.handle.net/YU.REPOSITORY/25754http://dx.doi.org/10.1111/j.1447-0594.2010.00649.x
ISSN
1444-1586
Appears in Collections:
의과대학 > 신경과학교실 > Articles
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