Seroepidemiologic Survey of Varicella-Zoster Virus in Korean Adults Using Glycoprotein Enzyme Immuno Assay and Fluorescent Antibody to Membrane Antigen Test

Title
Seroepidemiologic Survey of Varicella-Zoster Virus in Korean Adults Using Glycoprotein Enzyme Immuno Assay and Fluorescent Antibody to Membrane Antigen Test
Author(s)
박호선이태윤최종수김윤화황지영[황지영]이경민[이경민]최진희
Keywords
CELL-MEDIATED-IMMUNITY; HERPES-ZOSTER; VACCINE; RESPONSES
Issue Date
201102
Publisher
KOREAN DERMATOLOGICAL ASSOC
Citation
ANNALS OF DERMATOLOGY, v.23, no.1, pp.39 - 43
Abstract
Background: Herpes zoster (HZ) occurs mainly in the elderly and Korea is rapidly becoming an aging society. Therefore, it is important to know the immune status against varicella-zoster virus (VZV) in Korean adults to prevent the disease. Objective: The aim of this study was to survey the immune status of Korean adults over 40 years of age against VZV. Methods: Antibody titer was measured using a VaccZyme (TM) VZV glycoprotein enzyme immunoassay (gpEIA) (Binding Site, UK). Fluorescent antibody to membrane antigen (FAMA) test was performed to measure the seropositive rate. Results: HZ incidence in the 214 adults enrolled in this study was 10.3%. The gpEIA geometric mean titer (GMT) was 490 mIU/ml and 90.2% of the subjects had a protective level of gpEIA antibody titer against varicella. The average gpEIA GMT of adults who previously had HZ was 1,122 which was higher than the average gpEIA GMT of 457 mIU/ml in adults who had not had HZ. The FAMA positive rate was 98.6%. Conclusion: Most (90.2%) Korean adults >= 40-years-of-age have a protective level of gpEIA antibody against varicella and 98.6% were FAMA seropositive. The GMT of gpEIA antibody was significantly increased with age, and was higher in adults with a history of HZ. (Ann Dermatol 23(1) 39 similar to 43, 2011)
URI
http://hdl.handle.net/YU.REPOSITORY/25700http://dx.doi.org/10.5021/ad.2011.23.1.39
ISSN
1013-9087
Appears in Collections:
의과대학 > 미생물학교실 > Articles
의과대학 > 피부과학교실 > Articles
의과대학 > 영상의학과학교실 > Articles
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