Clinical Evaluation of Efficacy and Tolerability of HMC05 in Healthy Subjects with Normal and High-Normal Blood Pressure: A Pilot Study

Title
Clinical Evaluation of Efficacy and Tolerability of HMC05 in Healthy Subjects with Normal and High-Normal Blood Pressure: A Pilot Study
Author(s)
임미선이혜원[이혜원]성숙진[성숙진]박정현[박정현]이주미[이주미]서정주[서정주]김성두[김성두]신흥묵[신흥묵]윤영란[윤영란]
Keywords
FLOW-MEDIATED VASODILATION; C-REACTIVE PROTEIN; CARDIOVASCULAR-DISEASE; NITRIC-OXIDE; HYPERTENSION; HOMOCYSTEINE; MARKERS; BIOMARKERS; GUIDELINES; HUMANS
Issue Date
201102
Publisher
GEORG THIEME VERLAG KG
Citation
PLANTA MEDICA, v.77, no.3, pp.221 - 225
Abstract
HMC05, a formulation containing eight different herbal extracts, has been used widely for several thousand years in China, Japan, and Korea as a remedy for hypertension and headache. Although its anti-inflammatory effects in mouse monocytic cell lines and anti-atherosclerotic effects in apoE-knockout mice have been reported, the pharmacodynamic effects of HMC05 in human subjects have not yet been investigated. We evaluated the efficacy and tolerability of this drug in 14 healthy male Korean subjects with normal or high-normal blood pressure (BP) in a randomized, single-blind, crossover study with a 2-week washout period. Four 500-mg tablets of HMC05 or placebo were orally administered three times daily to nine subjects with normal BP and five subjects with high-normal BP for 4 weeks. To assess the pharmacodynamic effects of HMC05, levels of high-sensitivity C-reactive protein and homocysteine, BP, and flow-mediated vasodilation were measured before and after the 4-week medication period with evaluation of tolerability. All 14 subjects completed the study, and HMC05 was well tolerated with no significant adverse events. HMC05 did not exhibit a significant BP-lowering effect in either BP group, and there were no significant differences in other pharmacodynamic values after HMC05 or placebo administration in the two groups. Further study is needed to evaluate the efficacy and tolerability of HMC05 in an adequate number of patients with hypertension.
URI
http://hdl.handle.net/YU.REPOSITORY/25677http://dx.doi.org/10.1055/s-0030-1250237
ISSN
0032-0943
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약학대학 > 약학부 > Articles
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