Suppression of mast-cell-mediated allergic inflammation by Lindera obtusiloba

Title
Suppression of mast-cell-mediated allergic inflammation by Lindera obtusiloba
Author(s)
이승호김상현[김상현]서원모[서원모]박승빈[박승빈]이소영[이소영]김희훈[김희훈]석경호[석경호]손준호[손준호]권택규[권택규]최현규[최현규]
Keywords
NF-KAPPA-B; NECROSIS-FACTOR-ALPHA; HISTAMINE-RELEASE; CYTOKINE PRODUCTION; MURINE MACROPHAGES; SUBSTANCE-P; TNF-ALPHA; ANAPHYLAXIS; INHIBITION; MECHANISMS
Issue Date
201102
Publisher
SOC EXPERIMENTAL BIOLOGY MEDICINE
Citation
EXPERIMENTAL BIOLOGY AND MEDICINE, v.236, no.2, pp.240 - 246
Abstract
Allergic disease is a consequence of exposure to normally innocuous substances that elicit the activation of mast cells. Mast-cell-mediated allergic response is involved in many diseases such as anaphylaxis, allergic rhinitis, asthma and atopic dermatitis. The discovery of drugs for the treatment of allergic disease is an important subject in human health. In this study, we investigated the effect of Lindera obtusiloba water extract (LOWE) on the mast-cell-mediated allergic inflammation and possible mechanism of action using in vitro and in vivo models. LOWE reduced histamine release from various types of mast cells activated by immunoglobulin E (IgE) or phorbol 1 2-myristate 13-acetate and calcium ionophore A23187 (PMACI). The inhibitory effect of LOWE on histamine release was mediated by calcium signal. LOWE decreased the PMACI-stimulated gene expression of proinflammatory cytokines such as tumor necrosis factor-alpha and interleukin-6 in human mast cells. The inhibitory effect of LOWE on the proinflammatory cytokines was nuclear factor (NF)-kappa B dependent. In addition, LOWE suppressed compound 48/80-induced systemic allergic reaction and serum histamine release in mice and IgE-mediated local allergic reactions. Our results indicate that LOWE inhibits mast-cell-derived allergic inflammation and involvement of calcium, histamine, proinflammatory cytokines and NF-kappa B in these effects.
URI
http://hdl.handle.net/YU.REPOSITORY/25667http://dx.doi.org/10.1258/ebm.2010.010274
ISSN
1535-3702
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약학대학 > 약학부 > Articles
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