In Vivo Immunomodulating Activities of Ethanolic Leaf Extract of Stevia rebaudiana in Albino Rats

Title
In Vivo Immunomodulating Activities of Ethanolic Leaf Extract of Stevia rebaudiana in Albino Rats
Author(s)
김명희슈리티슈클라Mehta Archana[Mehta Archana]Ayyadurai N[Ayyadurai N]
Keywords
STEVIOSIDE; AYURVEDA
Issue Date
201102
Publisher
RESEARCH JOURNAL BIOTECHNOLOGY
Citation
RESEARCH JOURNAL OF BIOTECHNOLOGY, v.6, no.1, pp.27 - 31
Abstract
The present study was undertaken to explore the in vivo immunomodulating activities of ethanolic leaf extract of Stevia rebaudiana (Bertoni) in albino rats. The immunomodulatory activities were determined by neutrophil adhesion test, haemagglutinating antibody (HA) titre, delayed type hypersensitivity (DTH) response and phagocytic activity. The response produced by oral administration of ethanolic leaf extract showed a significant increase in neutrophil adhesion and delayed type hypersensitivity (DTH) response. With 300, 400 and 500 mg/kg/day doses of the extract, the DTH responses of 24 h (mean +/- SD % increase in paw volume) were found to be 0.41 +/- 0.01, 0.50 +/- 0.01 and 0.58 +/- 0.01 respectively as compared to the corresponding value of 0.18 +/- 0.01 for the control group. These differences in DTH response were statistically significant (P < 0.05). The augmentation of humoral immune response to sheep red blood cells by ethanolic extract (200 - 500 mg/kg) was evident by increase in antibody titres in rats. A dose-related increase in antibody titres was observed. The ethanolic leaf extract also evoked potent response towards phagocytosis in carbon clearence assay. This study demonstrates potent immunomodulatory activities and therapeutic potential of Stevia rebaudiana ethanolic leaf extract for the prevention of immunological disorders.
URI
http://hdl.handle.net/YU.REPOSITORY/25666
ISSN
0973-6263
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자연자원대학 > 식품공학과 > Articles
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