Design, synthesis and docking study of 5-amino substituted indeno[1,2-c]isoquinolines as novel topoisomerase I inhibitors

Title
Design, synthesis and docking study of 5-amino substituted indeno[1,2-c]isoquinolines as novel topoisomerase I inhibitors
Author(s)
Daulat Bikram Khadka[Daulat Bikram Khadka]Quynh Manh Le[Quynh Manh Le]양수희[양수희]Hue Thi My Van[Hue Thi My Van]Thanh Nguyen Le[Thanh Nguyen Le]조숙희[조숙희]권영주[권영주]이경태[이경태]이응석조원제[조원제]
Keywords
DRUG CAMPTOTHECIN; CYTOTOXICITY; 3-ARYLISOQUINOLINES; AGENTS; RING
Issue Date
201103
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
BIOORGANIC & MEDICINAL CHEMISTRY, v.19, no.6, pp.1924 - 1929
Abstract
Various 5-amino group-substituted indeno[1,2-c]isoquinolines 7a-f were synthesized based on the previous QSAR study as rigid structures of 3-arylisoquinolines. Amino group-substituted compounds, especially 5-piperazinyl indeno[1,2-c]isoquinoline 7f, displayed potent topoisomerase I inhibitory activity as well as cytotoxicities against five different tumor cell lines. A Surflex-Dock docking model of 7f was also studied. (C) 2011 Elsevier Ltd. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/25576http://dx.doi.org/10.1016/j.bmc.2011.01.064
ISSN
0968-0896
Appears in Collections:
약학대학 > 약학부 > Articles
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