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dc.contributor.author용철순ko
dc.contributor.author백형희[백형희]ko
dc.contributor.author권소영[권소영]ko
dc.contributor.author노신정[노신정]ko
dc.contributor.author이원석[이원석]ko
dc.contributor.author양호준[양호준]ko
dc.contributor.author하정미[하정미]ko
dc.contributor.author최한곤[최한곤]ko
dc.contributor.author김용로[김용로]ko
dc.date.accessioned2015-12-17T01:32:56Z-
dc.date.available2015-12-17T01:32:56Z-
dc.date.created2015-11-13-
dc.date.issued201103-
dc.identifier.citationARCHIVES OF PHARMACAL RESEARCH, v.34, no.3, pp.391 - 397-
dc.identifier.issn0253-6269-
dc.identifier.urihttp://hdl.handle.net/YU.REPOSITORY/25570-
dc.identifier.urihttp://dx.doi.org/10.1007/s12272-011-0306-x-
dc.description.abstractThe effect of cycloamylose on the aqueous solubility of flurbiprofen was investigated. To improve the solubility and bioavailability of flurbiprofen (poor water solubility), a solid dispersion was spray dried with a solution of flurbiprofen and cycloamylose at a weight ratio of 1:1. The physicochemical properties of solid dispersions were investigated using SEM, DSC, and X-ray diffraction. The dissolution and bioavailability in rats were evaluated compared with a commercial product. Cycloamylose increased solubility of flurbiprofen approximately 12-fold and dissolution of it by 2-fold. Flurbiprofen was present in an unchanged crystalline state, and cycloamylose was a solubilizing agent for flurbiprofen in this solid dispersion. Furthermore, the dispersion gave higher AUC and C(max) values compared with the commercial product, indicating that it improved the oral bioavailability of flurbiprofen in rats. Thus, the solid dispersion may be useful to deliver flurbiprofen with enhanced bioavailability without changes in crystalline structure.-
dc.language영어-
dc.publisherPHARMACEUTICAL SOC KOREA-
dc.subjectSPRAY-DRYING TECHNIQUE-
dc.subjectCYCLODEXTRIN INCLUSION COMPLEX-
dc.subjectSOLID DISPERSIONS-
dc.subjectORAL BIOAVAILABILITY-
dc.subjectBETA-CYCLODEXTRIN-
dc.subjectDISSOLUTION-
dc.subjectIBUPROFEN-
dc.subjectFORMULATION-
dc.subjectIMPROVEMENT-
dc.subjectDRUG-
dc.titleEnhanced Solubility and Bioavailability of Flurbiprofen by Cycloamylose-
dc.typeArticle-
dc.identifier.wosid000289120300007-
dc.identifier.scopusid2-s2.0-79959970646-
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