Azithromycin as a new chiral selector in capillary electrophoresis

Title
Azithromycin as a new chiral selector in capillary electrophoresis
Author(s)
박정학프라빈쿠마르
Keywords
STATIONARY-PHASE; ENANTIOMERIC SEPARATION; MACROCYCLIC ANTIBIOTICS; LIQUID-CHROMATOGRAPHY; BASIC DRUGS; CLINDAMYCIN PHOSPHATE; REVERSED-PHASE; VANCOMYCIN; CE; ENANTIOSEPARATIONS
Issue Date
201103
Publisher
ELSEVIER SCIENCE BV
Citation
JOURNAL OF CHROMATOGRAPHY A, v.1218, no.9, pp.1314 - 1317
Abstract
In capillary electrophoresis (CE), separation of enantiomers of a chiral compound can be achieved through the chiral interactions and/or complex formation between the chiral selector and the enantiomeric analytes on leaving their diastereomeric forms with different stability constants and hence different mobilities. A great number of chiral selectors have been employed in CE and among them macrocyclic antibiotics exhibited excellent enantioselective properties towards a wide number of racemic compounds. The use of azithromycin (AZM) as a chiral selector has not been reported previously. This work reports the use of AZM as a chiral selector for the enantiomeric separations of five chiral drugs and one amino acid (tryptophan) in CE. The enantioseparation is carried out using polar organic mixtures of acetonitrile (ACN), methanol (MeOH). acetic acid and triethylamine as run buffer. The influences of the chiral selector concentration, ACN/MeOH ratio, applied voltage and capillary temperature on enantioseparation are investigated. The results show that AZM is a viable chiral selector in CE for the enantioseparation of the type of chiral drugs investigated. (C) 2010 Elsevier B.V. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/25559http://dx.doi.org/10.1016/j.chroma.2010.12.106
ISSN
0021-9673
Appears in Collections:
이과대학 > 화학생화학부 > Articles
문과대학 > 중국언어문화학과 > Articles
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