Multicenter phase II trial of S-1, paclitaxel and cisplatin triplet combination chemotherapy in patients with advanced gastric cancer

Title
Multicenter phase II trial of S-1, paclitaxel and cisplatin triplet combination chemotherapy in patients with advanced gastric cancer
Author(s)
이경희김진영[김진영]도영록[도영록]박건욱[박건욱]김종광[김종광]채이수[채이수]김민경류헌모[류헌모]배성화[배성화]백진호[백진호]송홍석[송홍석]
Keywords
1ST-LINE THERAPY; 3-HOUR INFUSION; SUPPORTIVE CARE; PLUS CISPLATIN; 5-FLUOROURACIL; FLUOROURACIL; DOCETAXEL; I/II; METHOTREXATE; CARCINOMA
Issue Date
201103
Publisher
SPRINGER
Citation
CANCER CHEMOTHERAPY AND PHARMACOLOGY, v.67, no.3, pp.527 - 532
Abstract
The present study was conducted to evaluate the efficacy and safety of a combination regimen of S-1, paclitaxel plus cisplatin in patients with advanced gastric cancer. Patients with previously untreated metastatic or recurrent, measurable gastric cancer received intravenous paclitaxel 80 mg/m(2) plus cisplatin 30 mg/m(2) on days 1, 8 and S-1 35 mg/m(2) orally twice daily on days 1-14 based on a 3-week cycle. Forty-four patients were enrolled in the current study, among whom 38 were assessable for efficacy and all assessable for toxicity. Two complete response and 24 partial responses were confirmed, giving an overall response rate of 59.1%. At a median follow-up of 11.4 months, the median time to progression and median overall survival was 9.4 (95% CI 6.8-12.1) months and 11.2 (95% CI 7.6-14.8) months, respectively. Grade 3/4 neutropenia occurred in 45 events (20.9%) and febrile neutropenia was observed in five events (2.3%). The common non-hematologic toxicity was nausea (grade 1/2, 27.2%) and diarrhea (grade 1/2, 9.0%). The combination of S-1, paclitaxel and cisplatin was found to be well tolerated and effective in patients with advanced gastric cancer.
URI
http://hdl.handle.net/YU.REPOSITORY/25539http://dx.doi.org/10.1007/s00280-010-1353-6
ISSN
0344-5704
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의과대학 > 내과학교실 > Articles
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