Epifriedelanol from the Root Bark of Ulmus davidiana Inhibits Cellular Senescence in Human Primary Cells

Title
Epifriedelanol from the Root Bark of Ulmus davidiana Inhibits Cellular Senescence in Human Primary Cells
Author(s)
김재룡양효현손종근정보찬[정보찬]젱밍산[젱밍산]
Keywords
HUMAN DERMAL FIBROBLASTS; REPLICATIVE SENESCENCE; CHONDROCYTE SENESCENCE; NITRIC-OXIDE; DNA-DAMAGE; INNER BARK; GLYCOSIDES; CONSTITUENTS; LEAVES; SKIN
Issue Date
201103
Publisher
GEORG THIEME VERLAG KG
Citation
PLANTA MEDICA, v.77, no.5, pp.441 - 449
Abstract
Since cellular senescence involves organismal aging as well as diverse diseases, aging intervention might contribute to inhibit the aging process as well as aging-associated diseases. We tried to search for effective compounds from the root bark of Ulmus davidiana that are able to inhibit cellular senescence in human fibroblasts (HDFs) and human umbilical vein endothelial cells (HUVECs). Twenty-two compounds from the root bark of U. davidiana were isolated and screened for their inhibitory effects on adriamycin-induced cellular senescence by measuring senescence-associated beta-galatosidase (SA-beta-gal) activity. Among twenty-two compounds isolated, epifriedelanol (3), ssioriside (15), and catechin-7-O-beta-D-gluco-pyranoside (22) had inhibitory effects on adriamycin-induced cellular senescence in HDFs. Friedelin (2), epifriedelanol (3), and catechin-7-O-beta-apiofuranoside (18) were active in HUVECs. In particular, epifriedelanol (3) suppressed adriamycin-induced cellular senescence as well as replicative senescence in HDFs and HUVECs. These results suggest that epifriedelanol (3) reduces cellular senescence in human primary cells and might be used to develop dietary supplements or cosmetics that modulate tissue aging or aging-associated diseases.
URI
http://hdl.handle.net/YU.REPOSITORY/25515http://dx.doi.org/10.1055/s-0030-1250458
ISSN
0032-0943
Appears in Collections:
의과대학 > 생화학.분자생물학교실 > Articles
약학대학 > 약학부 > Articles
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