Phomalevones A-C: Dimeric and Pseudodimeric Polyketides from a Fungicolous Hawaiian Isolate of Phoma sp. (Cucurbitariaceae)

Title
Phomalevones A-C: Dimeric and Pseudodimeric Polyketides from a Fungicolous Hawaiian Isolate of Phoma sp. (Cucurbitariaceae)
Author(s)
심상희James Gloer[James Gloer]Jonas Baltrusaitis[Jonas Baltrusaitis]Donald Wicklow[Donald Wicklow]
Keywords
APPROXIMATE COULOMB POTENTIALS; AUXILIARY BASIS-SETS; XANTHONE BIOSYNTHESIS; ABSOLUTE-CONFIGURATION; METABOLITES; EXCHANGE; DENSITY; ATOMS
Issue Date
201103
Publisher
AMER CHEMICAL SOC
Citation
JOURNAL OF NATURAL PRODUCTS, v.74, no.3, pp.395 - 401
Abstract
Phomalevones A-C (1-3), three new compounds with bis-dihydroxanthone and bis-benzophenone systems, were isolated from cultures of a Hawaiian isolate of Phoma sp. (MYC-1734 = NRRL, 39060; Cucurbitariaceae). The structures of 1-3 were determined by analysis of NMR and MS data. The absolute configurations of the sp(3) stereocenters in the monomeric unit of 1 were assigned by application of Mosher's method, and overall absolute. configurations were proposed on the basis of ECD data using both computational methods and comparisons with literature data for model compounds. All three compounds showed antibacterial activity, and compounds 2 and 3 also exhibited antifungal effects.
URI
http://hdl.handle.net/YU.REPOSITORY/25513http://dx.doi.org/10.1021/np100791b
ISSN
0163-3864
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생명공학부 > 생명공학부 > Articles
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