Synthesis and anticoagulant activity of a new series of 1,4-dihydropyridine derivatives

Title
Synthesis and anticoagulant activity of a new series of 1,4-dihydropyridine derivatives
Author(s)
아크베르이드하야둘라R.Surendra Kumar[R.Surendra Kumar]A.Jamal Abdul Nasser[A.Jamal Abdul Nasser]J.Selvin[J.Selvin]
Keywords
SUBSTITUTED 2,5-DIOXO-1,2,3,4,5,6,7,8-OCTAHYDROQUINOLINES; AGENTS; ANTAGONISTS; COMPLEXES; LIGANDS; SOLVENT; ANALOGS
Issue Date
201103
Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Citation
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v.46, no.2, pp.804 - 810
Abstract
A series of 1,4-dihydropyridine derivatives (1a-g) were prepared from three compounds condensation reaction of ethylacetoacetate, aromatic aldehyde and ammonium hydroxide. A new series of compounds (2a-g) were prepared from compounds (1a-g) via reaction with thiosemicarbazide using the condensation method. The synthesized compounds were confirmed by IR, (1)H NMR, (13)C NMR, mass spectral and elemental analyses. The synthesized compounds (1a-g) and (2a-g) were also screened for anticoagulant properties. (C) 2010 Elsevier Masson SAS. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/25500http://dx.doi.org/10.1016/j.ejmech.2010.12.006
ISSN
0223-5234
Appears in Collections:
공과대학 > 화학공학부 > Articles
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