Non-disturbing of Decidual Response by Steroid Hormonal Complexes of Pig Testis

Title
Non-disturbing of Decidual Response by Steroid Hormonal Complexes of Pig Testis
Author(s)
최인호유자현[유자현]변지현[변지현]전소라[전소라]이동목전태훈[전태훈]이기호[이기호]전용필[전용필]
Keywords
Testis derived steroid hormonal complex; Artificial decidualization; Uterine responsibility.
Issue Date
201103
Publisher
한국발생생물학회
Citation
발생과 생식, v.15, no.1, pp.53 - 59
Abstract
Sex steroid hormones are key molecules to prepare the decidual response and their levels are important in this process. Imbalances of the levels of steroid hormones are cause of implantation failure and other diseases including physical weakness. Androgen replacement therapy or selective androgen receptor modulator are used to overcome various diseases but long-term use may cause of side effects. In previous report, it is suggested that the steroid hormonal complexes derived from pig enhance the proliferation of satellite cell. Therefore, to evaluate the possible usage of steroid hormonal complex derived from pig testis (tS-C), the effects of tS-C on uterine response were studied using the model of artificial decidua. tS-C did not disturb the rhythmical estrus cycle. Artificial-induced decidual response was normally induced in tS-C administered mice. The histological characters of the decidua of tS-C administered mice were not different from the vehicle. The expression patterns of molecular markers of decidua were not different between vehicle and tS-C group. Collectively these results suggested that tS-C does not disturb the uterine responsibility to the embryo. In addition, our results suggested that tS-C can be applied to overcome the various problems such as loss of muscle mass and anemia.
URI
http://hdl.handle.net/YU.REPOSITORY/25494
ISSN
1226-6752
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생명공학부 > 생명공학부 > Articles
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