경북산 현삼과 중국산 현삼의 비교: Harpagoside 함량 및 Nitric Oxide 저해활성

Title
경북산 현삼과 중국산 현삼의 비교: Harpagoside 함량 및 Nitric Oxide 저해활성
Other Titles
Comparison of the Scrophulariae Radix of Gyeongbuk's with that of Chinese: Content of Harpagoside and Inhibitory Effect of Nitric Oxide
Author(s)
나민균장해연[장해연]김금진[김금진]황인현[황인현]조희재[조희재]이승호
Keywords
Scrophulariae Radix; Scrophulariaceae; E-harpagoside; Quantitative analysis; Inhibition of nitric oxide
Issue Date
201103
Publisher
한국생약학회
Citation
생약학회지, v.42, no.1, pp.15 - 21
Abstract
Scrophulariae Radix (Scrophulariaceae) has been traditionally used to treat pharyngitis, laryngitis, tonsillitis, fever,and edema. To compare the quality of the Scrophulariae Radix produced from Gyeongbuk with that from China, a quantitative analysis on the major component, E-harpagoside, was performed by reversed-phase HPLC, and a relative inhibitory activity of nitric oxide (NO) was assayed in the Raw 264.7 cells. Using a Luna C18(2) column, we carried out quantitative analysis with a gradient of 0.1% phosphoric acid in water and acetonitrile. Our results demonstrated that the content of E-harpagoside in Gyeongbuk's Scrophulariae Radix were three times higher than that of Chinese. Moreover, the inhibitory activity of Scrophulariae Radix of Gyeongbuk's in the lipopolysaccharide (LPS)-induced NO production was higher than that of Chinese.
URI
http://hdl.handle.net/YU.REPOSITORY/25466
ISSN
0253-3073
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약학대학 > 약학부 > Articles
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