Orthosiphon stamineus Reduces Appetite and Visceral Fat in Rats

Title
Orthosiphon stamineus Reduces Appetite and Visceral Fat in Rats
Author(s)
김용운손조영박소영김종연원규장김용대최윤정Zheng Ming Shan[Zheng Ming Shan]손종근
Keywords
ISOPIMARANE-TYPE DITERPENES; SPRAGUE-DAWLEY RATS; STANDARDIZED EXTRACT; OBESITY; BENTH; INDONESIA; MICE; ANTIOBESITY; TOXICITY; ACID
Issue Date
201104
Publisher
KOREAN SOC APPLIED BIOLOGICAL CHEMISTRY
Citation
JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY, v.54, no.2, pp.200 - 205
Abstract
To evaluate whether Orthosiphon stamineus (OS) reduces appetite and fat deposition, food intake and visceral fat mass following treatment with OS (450 mg/kg/day, per oral) for 2 weeks in Sprague-Dawley (SD) rats were measured. Hypothalamic neuropeptides associated with appetite regulation was also analyzed. Two weeks of OS treatment reduced food intake and visceral fat mass compared to saline-treated SD rats. OS treatment for 2 weeks elevated the expression of proopiomelanocortin (POMC) in the hypothalamus, whereas neuropeptide Y (NPY) expression was decreased, which may be associated with the elevation of plasma leptin concentration in OS-treated rats. Methanol and butanol extracts of OS increased leptin mRNA expression in 3T3-L1 cells in dose-dependent manner. Acute study showed intraperitoneal injection of various concentrations of OS increased POMC expression in the hypothalamus, whereas NPY expression decreased dose-dependently. These results suggest that OS reduces appetite, which may have resulted from the increased expression of POMC and decreased expression of NPY in the hypothalamus in association with the elevation of leptin. OS could be a medicinal food applicable for body weight control.
URI
http://hdl.handle.net/YU.REPOSITORY/25405http://dx.doi.org/10.3839/jksabc.2011.033
ISSN
1738-2203
Appears in Collections:
의과대학 > 생리학교실 > Articles
의과대학 > 내과학교실 > Articles
의과대학 > 이비인후과학교실 > Articles
약학대학 > 약학부 > Articles
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