Effects of Rutaecarpine on the Pharmacokinetics of Caffeine and Its Three Metabolites in Rats

Title
Effects of Rutaecarpine on the Pharmacokinetics of Caffeine and Its Three Metabolites in Rats
Author(s)
서영민노금한[노금한]공민정[공민정]이대훈[이대훈]강미정[강미정]장영동강원구정병선정태천
Keywords
TANDEM MASS-SPECTROMETRY; EVODIA-RUTAECARPA; LIVER-MICROSOMES; INDUCTION; THEOPHYLLINE; INHIBITOR; ENZYMES; CYP1A2; MOUSE
Issue Date
201104
Publisher
KOREAN SOC APPLIED PHARMACOLOGY
Citation
BIOMOLECULES & THERAPEUTICS, v.19, no.2, pp.243 - 247
Abstract
Rutaecarpine, an alkaloid originally isolated from the unripe fruit of Evodia rutaecarpa, has been shown to be anti-inflammatory. In the present study, a possible interaction between rutaecarpine and caffeine was investigated in male Sprague Dawley rats. Twenty four hr after the oral pretreatment with rutaecarpine at 80 mg/kg for three consecutive days, rats were treated intravenously with 10 mg/kg of caffeine. Compared with control rats, the pharmacokinetic parameters of caffeine in rutaecarpine-pretreated rats were significantly changed, possibly due to the rapid metabolism. The production of three metabolites of caffeine (i.e., paraxanthine, theobromine and theophylline) was also significantly changed in rats pretreated with rutaecarpine. The present results suggest that oral rutaecarpine would change the intravenous pharmacokinetic characteristics of caffeine.
URI
http://hdl.handle.net/YU.REPOSITORY/25402http://dx.doi.org/10.4062/biomolther.2011.19.2.243
ISSN
1976-9148
Appears in Collections:
중앙도서관 > rims journal
약학대학 > 약학부 > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE