Effects of Rutaecarpine on the Pharmacokinetics of Caffeine and Its Three Metabolites in Rats
- Effects of Rutaecarpine on the Pharmacokinetics of Caffeine and Its Three Metabolites in Rats
- 서영민; 노금한[노금한]; 공민정[공민정]; 이대훈[이대훈]; 강미정[강미정]; 장영동; 강원구; 정병선; 정태천
- TANDEM MASS-SPECTROMETRY; EVODIA-RUTAECARPA; LIVER-MICROSOMES; INDUCTION; THEOPHYLLINE; INHIBITOR; ENZYMES; CYP1A2; MOUSE
- Issue Date
- KOREAN SOC APPLIED PHARMACOLOGY
- BIOMOLECULES & THERAPEUTICS, v.19, no.2, pp.243 - 247
- Rutaecarpine, an alkaloid originally isolated from the unripe fruit of Evodia rutaecarpa, has been shown to be anti-inflammatory. In the present study, a possible interaction between rutaecarpine and caffeine was investigated in male Sprague Dawley rats. Twenty four hr after the oral pretreatment with rutaecarpine at 80 mg/kg for three consecutive days, rats were treated intravenously with 10 mg/kg of caffeine. Compared with control rats, the pharmacokinetic parameters of caffeine in rutaecarpine-pretreated rats were significantly changed, possibly due to the rapid metabolism. The production of three metabolites of caffeine (i.e., paraxanthine, theobromine and theophylline) was also significantly changed in rats pretreated with rutaecarpine. The present results suggest that oral rutaecarpine would change the intravenous pharmacokinetic characteristics of caffeine.
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