Bioconjugation of L-3,4-Dihydroxyphenylalanine Containing Protein with a Polysaccharide

Title
Bioconjugation of L-3,4-Dihydroxyphenylalanine Containing Protein with a Polysaccharide
Author(s)
윤형돈니라이쿨람아야두레이나다라쟌 사라바난[나다라쟌 사라바난]카나가벨디판쿠마[카나가벨디판쿠마]장윤정나타라자키트라프리야[나타라자키트라프리야]송은정[송은정]이나훔[이나훔]김석규김병기[김병기]나가순다라판디안[나가순다라판디안]이선구[이선구]차형준[차형준]부디사[부디사]
Keywords
IN-VIVO; CHEMISTRY; VACCINES; BIOLOGY; CELLS
Issue Date
201104
Publisher
AMER CHEMICAL SOC
Citation
BIOCONJUGATE CHEMISTRY, v.22, no.4, pp.551 - 555
Abstract
We describe the simple bioconjugation strategy in combination of periodate chemistry and unnatural amino acid incorporation. The residue specific incorporation of 3,4-dihydroxy-L-phenylalanine can alter the properties of protein to conjugate into the polymers. The homogeneously modified protein will yield quinone residues that are covalently conjugated to nucleophilic groups of the amino polysaccharide. This novel approach holds great promise for widespread use to prepare protein conjugates and synthetic biology applications.
URI
http://hdl.handle.net/YU.REPOSITORY/25399http://dx.doi.org/10.1021/bc2000066
ISSN
1043-1802
Appears in Collections:
생명공학부 > 생명공학부 > Articles
문과대학 > 중국언어문화학과 > Articles
이과대학 > 화학생화학부 > Articles
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