Female patients with atrial fibrillation have increased oxidized and glycated lipoprotein properties and lower apolipoprotein A-I expression in HDL

Title
Female patients with atrial fibrillation have increased oxidized and glycated lipoprotein properties and lower apolipoprotein A-I expression in HDL
Author(s)
조경현김성민이지혜김재룡신동구이상희
Keywords
HIGH-DENSITY-LIPOPROTEIN; CORONARY-HEART-DISEASE; OXIDATIVE STRESS; MYOCARDIAL-INFARCTION; PURKINJE-FIBERS; PARTICLE-SIZE; HUMAN-SERUM; ATHEROGENESIS; RISK; LDL
Issue Date
201104
Publisher
SPANDIDOS PUBL LTD
Citation
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, v.27, no.6, pp.841 - 849
Abstract
It is well-known that oxidative stress and inflammatory processes are linked to the incidence of atrial fibrillation (AF). In order to provide prognostic biomarkers for AF based on lipoprotein levels, we compared the lipid and protein parameters of oxidation and inflammation in individual lipoproteins from middle-aged females with AF. We analyzed plasma and lipoproteins (VLDL, LDL, HDL(2), HDL(3)) from 11 female patients (mean age, 56 +/- 15 years) with paroxysmal lone AF and from a reference group of 10 female patients of similar age (mean age, 54 +/- 15 years). The AF group had normal levels of serum lipids and an inflammatory profile, except for a 7.5- and 6-fold elevation in hsCRP and tropoinin 1 levels, respectively. No significant differences existed in serum lipids, glucose, uric acid, creatinine and blood urea nitrogen levels between the AF and control groups. The lipoprotein particles from the AF group were more oxidized and glycated with higher triacylglycerol content compared to the control group and the particle size was smaller. The lipoprotein particles from the AF group promoted more foam cell formation via accelerated phagocytosis by macrophages compared to the control group. HDL(2) and HDL(3) from the AF group showed decreased antioxidant ability and an approximately 30% lower expression of apoA-I compared to the control group. All of these modified properties of lipoproteins, including oxidation and glycation, might be linked to the lower antioxidant ability and elevated inflammatory parameters in women with AF.
URI
http://hdl.handle.net/YU.REPOSITORY/25393http://dx.doi.org/10.3892/ijmm.2011.646
ISSN
1107-3756
Appears in Collections:
생명공학부 > 생명공학부 > Articles
의과대학 > 생화학.분자생물학교실 > Articles
의과대학 > 내과학교실 > Articles
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