Geraniol inhibits prostate cancer growth by targeting cell cycle and apoptosis pathways

Title
Geraniol inhibits prostate cancer growth by targeting cell cycle and apoptosis pathways
Author(s)
김태우[김태우]박현호김수화[김수화]배현철[배현철]박은정[박은정]이채륜[이채륜]김병주[김병주]이상훈[이상훈]김성준[김성준]서인석[서인석]전주홍[전주홍]
Keywords
ANDROGEN DEPRIVATION THERAPY; DEPENDENT KINASES; EXPRESSION; PROGRESSION; MODULATORS; RESISTANCE; RECEPTOR; BIOSYNTHESIS; FLAVOPIRIDOL; CHEMOTHERAPY
Issue Date
201104
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Citation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.407, no.1, pp.129 - 134
Abstract
The progression of prostate cancer is associated with escape from cell cycle arrest and apoptosis under androgen-depleted conditions. Here, we found that geraniol, a naturally occurring monoterpene, induces cell cycle arrest and apoptosis in cultured cells and tumor grafted mice using PC-3 prostate cancer cells. Geraniol modulated the expression of various cell cycle regulators and Bcl-2 family proteins in PC-3 cells in vitro and in vivo. Furthermore, we showed that the combination of sub-optimal doses of geraniol and docetaxel noticeably suppresses prostate cancer growth in cultured cells and tumor xenograft mice. Therefore, our findings provide insight into unraveling the mechanisms underlying escape from cell cycle arrest and apoptosis and developing therapeutic strategies against prostate cancer. (C) 2011 Elsevier Inc. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/25385http://dx.doi.org/10.1016/j.bbrc.2011.02.124
ISSN
0006-291X
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이과대학 > 화학생화학부 > Articles
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