5 '-Nitro-indirubinoxime, an indirubin derivative, suppresses metastatic ability of human head and neck cancer cells through the inhibition of Integrin beta 1/FAK/Akt signaling

Title
5 '-Nitro-indirubinoxime, an indirubin derivative, suppresses metastatic ability of human head and neck cancer cells through the inhibition of Integrin beta 1/FAK/Akt signaling
Author(s)
김수아[김수아]권성민[권성민]김정애강건욱[강건욱]윤정훈[윤정훈]안상건[안상건]
Keywords
ENDOTHELIAL GROWTH-FACTOR; GLAND ADENOCARCINOMA CELLS; TUMOR-CELL; CARCINOMA-CELLS; PROTEIN-KINASE; CYCLE ARREST; IN-VIVO; EXPRESSION; INVASIVENESS; ANGIOGENESIS
Issue Date
201104
Publisher
ELSEVIER IRELAND LTD
Citation
CANCER LETTERS, v.306, no.2, pp.197 - 204
Abstract
Head and neck cancer is a malignant cancer and has the high infiltrative potential leading to metastasis. The objective of the study was to investigate the effects of 5'-nitro-indirubinoxime (5'-NIO), an indirubin derivative, on metastasis of head and neck cancer cells and to explore the underlying molecular mechanisms involved in this process. After treatment of head and neck cancer cells with 5'-NIO, cell metastatic behaviors such as colony formation, invasion, and migration were inhibited in a concentration-dependent manner. 5'-NIO inhibited the betal Integrin/FAK/Akt pathway which can then facilitate invasion and/or migration of cancer cells through the extracellular matrix (ECM). Moreover, treatment of head and neck cancer cell with Integrin beta 1 siRNA or FAK inhibitor effectively inhibited the invasion and migration, suggesting their regulatory role at invasiveness and migratory of head and neck cancer cells. In vivo CAM assay, treatment with 5'-NIO reduced the angiogenesis in FaDu cells xenograft fertilized chicken eggs, primarily by inhibiting expression of VEGF. We conclude that 5'-NIO inhibits the metastatic ability of head and neck cancer cells by blocking the Integrin beta 1/FAK/Akt pathway. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/25382http://dx.doi.org/10.1016/j.canlet.2011.03.006
ISSN
0304-3835
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약학대학 > 약학부 > Articles
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