Dialysis modality-dependent changes in serum metabolites: accumulation of inosine and hypoxanthine in patients on haemodialysis

Title
Dialysis modality-dependent changes in serum metabolites: accumulation of inosine and hypoxanthine in patients on haemodialysis
Author(s)
도준영최지영[최지영]윤유정[윤유정]최희정[최희정]박선희[박선희]김찬덕[김찬덕]김인산[김인산]권태환[권태환]김성호[김성호]류도현[류도현]황금숙[황금숙]김용림[김용림]
Keywords
NUCLEAR-MAGNETIC-RESONANCE; AMBULATORY PERITONEAL-DIALYSIS; TRIMETHYLAMINE-N-OXIDE; STAGE RENAL-DISEASE; UREMIC TOXINS; OXIDATIVE STRESS; FREE CHOLINE; PLASMA; METABONOMICS; SPECTROSCOPY
Issue Date
201104
Publisher
OXFORD UNIV PRESS
Citation
NEPHROLOGY DIALYSIS TRANSPLANTATION, v.26, no.4, pp.1304 - 1313
Abstract
Background. The body metabolism of patients with end-stage renal disease may be altered in response to long-term dialysis treatment. Moreover, the pattern of serum metabolites could change depending on the type of dialysis modality used. However, dialysis modality-dependent changes in serum metabolites are poorly understood. Our aim was to profile comprehensively serum metabolites by exploiting a novel method of H-1-NMR-based metabonomics and identify the differences in metabolite patterns in subjects receiving haemodialysis (HD) and peritoneal dialysis (PD). Methods. Anuric and non-diabetic HD patients were matched to PD patients for age, sex and dialysis duration. Accurate concentrations of serum metabolites were determined using the target-profiling procedure, and differences in the levels of metabolites were compared using multivariate analysis. Results. Principal Components Analysis score plots showed that the metabolic patterns could be discriminated by dialysis modalities. Hypoxanthine and inosine were present only with HD, whereas serum xanthine oxidase activity and uric acid levels were not different. In contrast, PD was associated with higher levels of lactate, glucose, maltose, pyruvate, succinate, alanine, and glutamate linked to glucose metabolism and the tri-carboxylic acid cycle. Maltose appeared only in patients using icodextrin solution for PD. Known uraemic retention solutes such as urea, creatinine, myo-inositol and trimethylamine-N-oxide were increased in both dialysis groups. Conclusions. Metabonomics shows apparent differences in the profiles of serum metabolites between HD and PD, which were influenced by dialysis-related processes. Inosine and hypoxanthine are present only in HD patients, which is likely to represent more hypoxic and oxidative stress.
URI
http://hdl.handle.net/YU.REPOSITORY/25381http://dx.doi.org/10.1093/ndt/gfq554
ISSN
0931-0509
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의과대학 > 내과학교실 > Articles
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