A Prediction Rule to Identify Severe Cases among Adult Patients Hospitalized with Pandemic Influenza A (H1N1) 2009

Title
A Prediction Rule to Identify Severe Cases among Adult Patients Hospitalized with Pandemic Influenza A (H1N1) 2009
Author(s)
허지안오원섭[오원섭]이승준[이승준]이창섭[이창섭]허애정[허애정]허상택[허상택]박상원[박상원]배인규[배인규]김의석[김의석]김홍빈[김홍빈]송경호[송경호]이꽃실[이꽃실]이상록[이상록]염준섭[염준섭]이수진[이수진]김백남[김백남]곽이경[곽이경]이재훈[이재훈]김영근[김영근]김효열[김효열]김남중[김남중]오명돈[오명돈]박윤선[박윤선]
Keywords
CRITICALLY-ILL PATIENTS; INFECTION; MEXICO; VIRUS; PNEUMONIA; A(H1N1)
Issue Date
201104
Publisher
KOREAN ACAD MEDICAL SCIENCES
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE, v.26, no.4, pp.499 - 506
Abstract
The purpose of this study was to establish a prediction rule for severe illness in adult patients hospitalized with pandemic influenza A (H1N1) 2009. At the time of initial presentation, the baseline characteristics of those with severe illness (i.e., admission to intensive care unit, mechanical ventilation, or death) were compared to those of patients with non-severe illnesses. A total of 709 adults hospitalized with pandemic influenza A (H1N1) 2009 were included: 75 severe and 634 non-severe cases. The multivariate analysis demonstrated that altered mental status, hypoxia (PaO2/FiO(2) <= 250), bilateral lung infiltration, and old age (>= 65 yr) were independent risk factors for severe cases (all P < 0.001). The area under the ROC curve (0.834 [95% Cl, 0.778-0.8901) of the number of risk factors were not significantly different with that of APACHE II score (0.840 [95% Cl, 0.790-0.891]) (P = 0.496). The presence of >= 2 risk factors had a higher sensitivity, specificity, positive predictive value and negative predictive value than an APACHE II score of >= 13. As a prediction rule, the presence of >= 2 these risk factors is a powerful and easy-to-use predictor of the severity in adult patients hospitalized with pandemic influenza A (H1N1) 2009.
URI
http://hdl.handle.net/YU.REPOSITORY/25380http://dx.doi.org/10.3346/jkms.2011.26.4.499
ISSN
1011-8934
Appears in Collections:
의과대학 > 내과학교실 > Articles
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