20S Proteasome Inhibitory Activity of Flavonoids isolated from Spatholobus suberectus

Title
20S Proteasome Inhibitory Activity of Flavonoids isolated from Spatholobus suberectus
Author(s)
심상희
Keywords
APOPTOSIS; BORTEZOMIB; PATHWAY; TARGET
Issue Date
201104
Publisher
WILEY-BLACKWELL
Citation
PHYTOTHERAPY RESEARCH, v.25, no.4, pp.615 - 618
Abstract
The promising biological role of the ubiquitin proteasome pathway (UPP) in cancer therapy has recently emerged. Inhibition of proteasome has been proposed as a new therapeutic target for treatment of cancer. Bioassay-guided fractionation of a MeOH extract of the stems of Spatholobus suberectus resulted in seven compounds, liquiritigenin (1), isoliquiritigenin (2), genistein (3), daidzein (4), medicarpin (5), 7-hydroxyflavanone (6) and formononetin (7), which were evaluated for the first time for their inhibitory effect on 20S proteasome. Among the isolated compounds, 2, 3 and 6 exhibited inhibitory activities on human 20S proteasome with IC(50) values of 4.88 +/- 1.5, 9.26 +/- 1.2 and 5.21 +/- 1.5 mu M, respectively. Copyright (C) 2010 John Wiley & Sons, Ltd.
URI
http://hdl.handle.net/YU.REPOSITORY/25377http://dx.doi.org/10.1002/ptr.3342
ISSN
0951-418X
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생명공학부 > 생명공학부 > Articles
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