Direct numerical simulation of electrokinetic translocation of a cylindrical particle through a nanopore using a Poisson-Boltzmann approach

Title
Direct numerical simulation of electrokinetic translocation of a cylindrical particle through a nanopore using a Poisson-Boltzmann approach
Author(s)
스즈첸Ye Ai[Ye Ai]
Keywords
SURFACE-CHARGE DENSITY; ELECTROPHORETIC MOTION; SPHERICAL-PARTICLE; FINITE CYLINDER; IONIC-CURRENT; SYNTHETIC NANOPORES; CONTINUUM-THEORIES; DNA TRANSLOCATION; MICROCHANNEL; AXIS
Issue Date
201104
Publisher
WILEY-BLACKWELL
Citation
ELECTROPHORESIS, v.32, no.9, pp.996 - 1005
Abstract
Nanopore-based sensing of single molecules is based on a detectable change in the ionic current arising from the electrokinetic translocation of individual nanoparticles through a nanopore. In this study, we propose a continuum-based model to investigate the dynamic electrokinetic translocation of a cylindrical nanoparticle through a nanopore and the corresponding ionic current response. It is the first time to simultaneously solve the Poisson-Boltzmann equation for the ionic concentrations and the electric field contributed by the surface charges of the nanopore and the nanoparticle, the Laplace equation for the externally applied electric field, and the modified Stokes equations for the flow field using an arbitrary Lagrangian-Eulerian method. Current blockade due to the particle translocation is predicted when the electric double layers (EDLs) of the particle and the nanopore are not overlapped, which is in qualitative agreement with existing experimental observations. Effects due to the electric field intensity imposed, the EDL thickness, the nanopore's surface charge, the particle's initial orientation and lateral offset from the nanopore's centerline on the particle translocation including both translation and rotation, and the ionic current response are comprehensively investigated. Under a relatively low electric field imposed, the particle experiences a significant rotation and a lateral movement. However, the particle is aligned with its longest axis parallel to the local electric field very quickly due to the dielectrophoretic effect when the external electric field is relatively high.
URI
http://hdl.handle.net/YU.REPOSITORY/25367http://dx.doi.org/10.1002/elps.201000503
ISSN
0173-0835
Appears in Collections:
공과대학 > 기계공학부 > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE