Effectiveness of Drug-Eluting Stents versus Bare-Metal Stents in Large Coronary Arteries in Patients with Acute Myocardial Infarction

Title
Effectiveness of Drug-Eluting Stents versus Bare-Metal Stents in Large Coronary Arteries in Patients with Acute Myocardial Infarction
Author(s)
김영조심두선[심두선]정명호[정명호]안영근[안영근]채성철[채성철]홍택종[홍택종]성인환[성인환]채제건[채제건]김종진[김종진]조명찬[조명찬]성기배[성기배]박승정[박승정]
Keywords
TAXUS-IV TRIAL; RANDOMIZED-TRIAL; FOLLOW-UP; UNCOATED STENTS; VESSEL SIZE; RESTENOSIS; PREVENTION; DISEASE; IMPLANTATION; METAANALYSIS
Issue Date
201104
Publisher
KOREAN ACAD MEDICAL SCIENCES
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE, v.26, no.4, pp.521 - 527
Abstract
This study compared clinical outcomes of drug-eluting stents (DES) versus bare-metal stents (BMS) in large coronary arteries in patients with acute myocardial infarction (MI). A total of 985 patients who underwent single-vessel percutaneous coronary intervention (PCI) in large coronary arteries (>= 3.5 mm) in lesions < 25 mm were divided into DES group (n = 841) and BMS group (n = 144). Clinical outcomes during 12 months were compared. In-hospital outcome was similar between the groups. At six months, death/MI rate was not different. However, DES group had significantly lower rates of target-lesion revascularization (TLR) (1.7% vs 5.6%, P = 0.021), target-vessel revascularization (IVR) (2.2% vs 5.6%, P = 0.032), and total major adverse cardiac events (MACE) (3.4% vs 11.9%, P = 0.025). At 12 months, the rates of TLR and IVR remained lower in the DES group (2.5% vs 5.9%, P = 0.032 and 5.9% vs 3.1%, P = 0.041), but the rates of death/MI and total MACE were not statistically different. The use of DES in large vessels in the setting of acute MI is associated with lower need for repeat revascularization compared to BMS without compromising the overall safety over the course of one-year follow-up.
URI
http://hdl.handle.net/YU.REPOSITORY/25347http://dx.doi.org/10.3346/jkms.2011.26.4.521
ISSN
1011-8934
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의과대학 > 내과학교실 > Articles
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