Biostable Poly(ethylene oxide)-b-poly(methacrylic acid) Micelles forpH-triggered Release of Doxorubicin

Title
Biostable Poly(ethylene oxide)-b-poly(methacrylic acid) Micelles forpH-triggered Release of Doxorubicin
Author(s)
김종오용철순최한곤[최한곤]최영근이동원타티아나 브로니치[타티아나 브로니치]
Keywords
Doxorubicin; Block ionomer; Calcium; Cross-linked; Polymeric micelles
Issue Date
201104
Publisher
한국약제학회
Citation
Journal of Pharmaceutical Investigation, v.41, no.2, pp.111 - 115
Abstract
pH-sensitive cross-linked polymeric micelles were synthesized by using block ionomer complexes of poly(ethylene oxide)-b-poly(methacrylic acid) (PEO-b-PMA) with calcium ions as micellar templates. An anticancer drug, doxorubicin (DOX) was conjugated on the cross-linked ionic cores of micelles via acid-labile hydrozone bonds. The resulting DOX-conjugated, pH-sensitive micelles are stable at physiological conditions, whereas the release of DOX was significantly increased at the acidic pH. Such micelles were internalized to lysosomes, and acidic pH in lysosomes triggers the release of DOX upon internalization in MCF-7 breast cancer cells. The released DOX entered the cell nucleus and eventually killed cancer cells. Therefore, these data demonstrate that the pH-sensitive micelles could be a promising nanocarrier for delivery of anticancer drug, DOX.
URI
http://hdl.handle.net/YU.REPOSITORY/25322
ISSN
2093-5552
Appears in Collections:
약학대학 > 약학부 > Articles
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