High-Density Lipoprotein (HDL) From Elderly and Reconstituted HDL Containing Glycated Apolipoproteins A-I Share Proatherosclerotic and Prosenescent Properties With Increased Cholesterol Influx

Title
High-Density Lipoprotein (HDL) From Elderly and Reconstituted HDL Containing Glycated Apolipoproteins A-I Share Proatherosclerotic and Prosenescent Properties With Increased Cholesterol Influx
Author(s)
조경현박기훈
Keywords
LIPID-BOUND STATE; METABOLIC SYNDROME; LDL OXIDATION; CELLULAR SENESCENCE; DIETARY FRUCTOSE; END-PRODUCTS; APOA-I; ATHEROSCLEROSIS; MECHANISMS; CELLS
Issue Date
201105
Publisher
OXFORD UNIV PRESS INC
Citation
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, v.66, no.5, pp.511 - 520
Abstract
High-density lipoprotein (HDL) is a strong antioxidant, anti-inflammatory, and antisenescence molecule. However, in the current study. HDL from the elderly group (E-HDL) exhibited increased glycation with apolipoprotein (apo) A-I multimerization and decreased phospholipid content. Similarly, glycated apoA-I (gA-I) by fructosylation has a covalently multimerized band without a crosslinker and impaired phospholipid-binding ability. Treatment of human dermal fibroblasts and macrophages with E-HDL and gA-I caused more severe cellular senescence and foam cell formation, respectively; however, treatment with HDL from a young group (Y-HDL) and native apoA-I (nA-I) suppressed senescence and atherosclerosis. E-HDL(3) and reconstituted HDL, (rHDL) containing gA-I showed enhanced cholesterol influx into macrophages compared with Y-HDL(3) and nA-I-rHDL. In conclusion, E-HDL and gA-I-rHDL share similar physiologic properties in macrophages and human dermal fibroblasts. and gA-I-rHDL exacerbated cellular senescence and atherosclerosis with increased cellular cholesterol influx.
URI
http://hdl.handle.net/YU.REPOSITORY/25235http://dx.doi.org/10.1093/gerona/glr016
ISSN
1079-5006
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